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Dna Methylation and Microrna Patterns Are in Association With the Expression of Brca1 in Ovarian Cancer Publisher Pubmed



Shariatikohbanani M1 ; Zarebidaki M2 ; Taghavi MM1 ; Taghipour Z1 ; Shabanizadeh A1 ; Kennedy D3 ; Dahim H4 ; Salahshoor MR5 ; Jalili C5 ; Arababadi MK2
Authors
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Authors Affiliations
  1. 1. Dept. of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  2. 2. Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  3. 3. School of Natural Sciences and Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Australia
  4. 4. School of Pharmacy and Pharmacutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Cellular and Molecular Biology Published:2016


Abstract

Ovarian cancer is the sixth most prevalent cancer in women and is considered the most lethal gynecological malignancy. It can be inherited as a familial disease but also has a strong spontaneous occurrence. Although the disease is associated with genome instability brought on by genetics and environmental factors there is evidence that mutations in the gene encoding for the breast cancer type 1 susceptibility protein (BRCA1) or its down-regulation are involved in its development. Down-regulation of BRCA1 expression by hypermethylation of its promoter may account for some cases of ovarian cancer but this does not explain the cause of the majority of the disease. This review explores the role of BRCA1 promoter hypermethylation and micro-RNAs (miRNA) involved in the regulation of BRCA1 and their role in ovarian cancer development as well as some of the exciting discoveries which could lead to targeting miRNA with a view to restoring BRCA1 expression in diseased tissues. © 2016 by the C.M.B. Association.
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