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Combined Effects of Calcium Hydroxide and Photobiomodulation Therapy on Apexogenesis of Immature Permanent Teeth in Dogs Publisher Pubmed



Bahman S1 ; Sara G2 ; Somayeh H3 ; Parvin T4 ; Kalhori KAM5 ; Mona S6 ; Reza F7, 8
Authors
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Authors Affiliations
  1. 1. Dental Research Center, Pediatric Dentistry Department, School of Dentistry, Tehran University of Medical Science, Tehran, Iran
  2. 2. Laser Research Center, Pediatric Dentistry Department, School of Dentistry, Tehran University of Medical Science, Tehran, Iran
  3. 3. Dental Materials Research Center, Operative Dentistry Department, School of Dentistry, Tehran University of Medical Science, Isfahan, Iran
  4. 4. Department Of Orthodontics, School of Dentistry, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Oral & Maxillofacial Pathologist, Iranian Medical Laser Association, Iran
  6. 6. Pediatric Dentistry Department, School of Dentistry, Arak University of Medical Science, Arak, Iran
  7. 7. Radiation Sciences Research Center, Laser Research Center in Medical Sciences, AJA University of Medical Sciences, Tehran, Iran
  8. 8. International Network for Photo Medicine and Photo Dynamic Therapy (INPMPDT), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Journal of Photochemistry and Photobiology B: Biology Published:2020


Abstract

Treatment of high-risk traumatic immature teeth due to incomplete root development is challenging. Apexogenesis is currently the ideal treatment option that allows normal root development. The purpose of this study was to evaluate the apexogenesis process of immature permanent teeth of dogs when co-administered with calcium hydroxide and photobiomodulation therapy (PBMT). A total of 36 immature permanent anterior and premolar teeth were selected from three 4–6-month-old dogs of Iranian mixed generation. The teeth were categorized into two groups, calcium hydroxide with laser irradiation (CHL) and calcium hydroxide without laser irradiation (CH). All the selected teeth received calcium hydroxide pulpotomy. After restoring teeth with amalgam, the CHL group received gallium‑aluminum-arsenide (GaAlAs) diode laser (810 nm, 4.2 J/cm2, 0.3 W, 9 s,CW) on apical one-third of both buccal and lingual roots. The irradiation was repeated every 48 h for fourteen days. Intravenous tetracycline was used to observe newly formed dentin in the first, third, seventh, and fourteenth days. The distance between tetracycline lines (DTL) was examined by Fluorescence microscopy. Generalized estimating equations (GEE) were used for data analysis. In all assessments, the mean DTL were greater in the CHL group. However, the two groups had no significant differences in the amount of deposited dentin between the first and third, third and seventh, and first and seventh lines. Meanwhile, there was a significant difference between the two groups in terms of the distances between lines 7 and 14, 1 and 14 and also 3 to 14 (P <.001). In other words, from the 7th day onwards, there was a significant difference between the two groups. Within the limitation of this study, the combination therapy of PBMT and pulpotomy with calcium hydroxide accelerated apexogenesis in immature permanent dogs' teeth. © 2020 Elsevier B.V.
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