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Synthesis and Cytotoxic Evaluation of Some New 3-(2-(2-Phenylthiazol-4-Yl) Ethyl)-Quinazolin-4(3H) One Derivatives With Potential Anticancer Effects Publisher



Hosseinzadeh L1 ; Aliabadi A2 ; Rahnama M3 ; Sadeghi HMM4 ; Khajouei MR2
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Studes Research Committee, School of Pharmacy and Pharmaceutical Science, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Department of Biotechnology and Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Research in Pharmaceutical Sciences Published:2017


Abstract

Quinazolinones are a group of heterocyclic compounds that have important biological activities such as cytotoxicity, anti-bacterial, and anti-fungal effects. Thiazole-containing compounds have also many biological effects including antitumor, antibacterial, anti-inflammatory, and analgesic activities. Due to significant cytotoxic effects of both quinazoline and thiazole derivatives, in this work a group of quinazolinone-thiazol hybrids were prepared and their cytotoxic effects on three cell lines were evaluated using MTT assay. Compounds A3, A2 , B4 , and A1 showed highest cytotoxic activities against PC3 cell line. Compounds A3 , A5 , and A2 were most active against MCF-7 and A3 , A5 , and A6 showed good cytotoxic effect on HT-29 cell line. According to the results, A3 efficiently inhibited all cell growth tested in a dose dependent manner. The IC 50 of A3 was 10 M, 10 μM, and 12μM on PC3, MCF-7, and HT-29 cells, respectively.
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