Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Oncolytic Virus Delivery Modulated Immune Responses Toward Cancer Therapy: Challenges and Perspectives Publisher Pubmed



Keshavarz M1 ; Mohammad Miri S2 ; Behboudi E3 ; Arjeini Y4 ; Dianatmoghadam H5 ; Ghaemi A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
  2. 2. Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran
  4. 4. Department of Research and Development, Production and Research Complex, Pasteur Institute of Iran, Tehran, Iran
  5. 5. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Immunopharmacology Published:2022


Abstract

Oncolytic viruses (OVs) harness the hallmarks of tumor cells and cancer-related immune responses for the lysis of malignant cells, modulation of the tumor microenvironment, and exertion of vaccine-like activities. However, efficient clinical exploitation of these potent therapeutic modules requires their systematic administration, especially against metastatic and solid tumors. Therefore, developing methods for shielding a virus from the neutralizing environment of the bloodstream while departing toward tumor sites is a must. This paper reports the latest advancements in the employment of chemical and biological compounds aimed at safe and efficient delivery of OVs to target tissues or tumor deposits within the host. © 2022 Elsevier B.V.
Related Docs
View other Related Docs
1. Mesenchymal Stem Cell-Released Oncolytic Virus: An Innovative Strategy for Cancer Treatment, Cell Communication and Signaling (2023)
2. Oncolytic Newcastle Disease Virus Delivered by Mesenchymal Stem Cells-Engineered System Enhances the Therapeutic Effects Altering Tumor Microenvironment, Virology Journal (2020)
3. Immunotherapy a New Hope for Cancer Treatment: A Review, Pakistan Journal of Biological Sciences (2018)
4. Multifunctional Plant Virus Nanoparticles in the Next Generation of Cancer Immunotherapies, Seminars in Cancer Biology (2022)
5. Oncolytic Virotherapy Improves Immunotherapies Targeting Cancer Stemness in Glioblastoma, Biochimica et Biophysica Acta - General Subjects (2024)
6. Genetic Advancements in Breast Cancer Treatment: A Review, Discover Oncology (2025)
7. Engineered Small Extracellular Vesicles As a Novel Platform to Suppress Human Oncovirus-Associated Cancers, Infectious Agents and Cancer (2023)
8. Targeting Immune Checkpoints: How to Use Natural Killer Cells for Fighting Against Solid Tumors, Cancer Communications (2023)
Experts (# of related papers)
View all Related Experts
Hassan Dianat Moghadam (4)
Hossein Khanahmad (3)
Other Related Docs
9. Recent Advancements to Engineer Mesenchymal Stem Cells and Their Extracellular Vesicles for Targeting and Destroying Tumors, Progress in Biophysics and Molecular Biology (2023)
10. Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors, Vaccines (2022)
11. Gene Delivery by Pei-Nanocomplex Into Breast and Colorectal Tumor Cell Lines, the Impacts of N/P Ratio, Size and Type of the Cell; [Pei-Nanocomplex Tarafindan Meme Ve Kolorektal Tumor Hucre Hatlarinda Gen Dagitimi, N / P Oraninin, Hucrenin Boyutu Ve Turunun Etkileri], Fabad Journal of Pharmaceutical Sciences (2020)
12. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
13. Recent Progress in Cancer Immunotherapy: Application of Nano-Therapeutic Systems, Journal of Drug Delivery Science and Technology (2024)
14. Viral Nanoparticles-Mediated Delivery of Therapeutic Cargo, Advanced Therapeutics (2023)
15. Advanced Nanosystems for Cancer Therapeutics: A Review, ACS Applied Nano Materials (2023)
16. Cancer Virotherapy: Targeting Cancer Cells by Microrna Mechanism for Selective Replication of Oncolytic Viruses in These Cells, Koomesh (2022)
17. The Signaling Pathways, and Therapeutic Targets of Antiviral Agents: Focusing on the Antiviral Approaches and Clinical Perspectives of Anthocyanins in the Management of Viral Diseases, Frontiers in Pharmacology (2019)
18. Novel Drug and Vaccine Delivery Systems, Journal of Isfahan Medical School (2012)
19. Vault, Viral, and Virus-Like Nanoparticles for Targeted Cancer Therapy, Materials Advances (2023)
20. Chimeric Antigen Receptor-T Cells Immunotherapy for Targeting Breast Cancer, Research in Pharmaceutical Sciences (2021)
21. Advances in Bioengineered Car T/Nk Cell Therapy for Glioblastoma: Overcoming Immunosuppression and Nanotechnology-Based Strategies for Enhanced Car T/Nk Cell Therapy, Bioengineering and Translational Medicine (2024)
22. The Mrna Vaccines and Their Application to Combat Infectious Diseases and Cancers: A Review Article, Journal of Isfahan Medical School (2023)
23. Cytotoxic Effects of Chitosan/Retinoic Acid/Albumin Targeted Nanoparticles Loaded With Doxorubicin on Human Hepatoma Cells, Journal of Isfahan Medical School (2013)
24. Nanomaterials and Nanotechnology-Associated Innovations Against Viral Infections With a Focus on Coronaviruses, Nanomaterials (2020)
25. Preparation and Evaluation of Targeted Albumin Lipid Nanoparticles With Lactobionic Acid for Targeted Drug Delivery of Sorafenib in Hepatocellular Carcinoma, Journal of Drug Delivery Science and Technology (2022)
26. The Therapeutic Effect of Mscs and Their Extracellular Vesicles on Neuroblastoma, Progress in Biophysics and Molecular Biology (2024)
27. Exploring Metal-Organic Frameworks in Gene Delivery: From Prostate to Lung Therapeutics, Applied Materials Today (2024)
28. Polymeric Nanoparticles in Cancer Chemotherapy: A Narrative Review, Iranian Journal of Public Health (2022)
29. Immunologic Tumor Microenvironment Modulators for Turning Cold Tumors Hot, Cancer Communications (2024)