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Mesenchymal Stem Cell-Released Oncolytic Virus: An Innovative Strategy for Cancer Treatment Publisher Pubmed



Ghasemi Darestani N1 ; Gilmanova AI3 ; Algazally ME2 ; Zekiy AO3 ; Ansari MJ4 ; Zabibah RS5 ; Jawad MA6 ; Alshalah SAJ7 ; Rizaev JA8 ; Alnassar YS9 ; Mohammed NM10 ; Mustafa YF11 ; Darvishi M12 ; Akhavansigari R13, 14
Authors
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Authors Affiliations
  1. 1. Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. College of Medicine, University of Al-Ameed, Karbala, Iraq
  3. 3. Department of Prosthetic Dentistry of the I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
  4. 4. Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
  5. 5. Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
  6. 6. Al-Nisour University College, Baghdad, Iraq
  7. 7. Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Iraq
  8. 8. Department of Public Health and Healthcare Management, Rector, Samarkand State Medical University, Samarkand, Uzbekistan
  9. 9. The University of Mashreq, Baghdad, Iraq
  10. 10. Department of Pharmacy, Mazaya University College, Dhi Qar, Nasiriyah, Iraq
  11. 11. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq
  12. 12. Department of Aerospace and Subaquatic Medicine, Infectious Diseases and Tropical Medicine Research Center (IDTMRC), AJA University of Medical Sciences, Tehran, Iran
  13. 13. Department of Neurosurgery, University Medical Center, Tuebingen, Germany
  14. 14. Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University, Warsaw, Poland

Source: Cell Communication and Signaling Published:2023


Abstract

Oncolytic viruses (OVs) infect, multiply, and finally remove tumor cells selectively, causing no damage to normal cells in the process. Because of their specific features, such as, the ability to induce immunogenic cell death and to contain curative transgenes in their genomes, OVs have attracted attention as candidates to be utilized in cooperation with immunotherapies for cancer treatment. This treatment takes advantage of most tumor cells' inherent tendency to be infected by certain OVs and both innate and adaptive immune responses are elicited by OV infection and oncolysis. OVs can also modulate tumor microenvironment and boost anti-tumor immune responses. Mesenchymal stem cells (MSC) are gathering interest as promising anti-cancer treatments with the ability to address a wide range of cancers.MSCs exhibit tumor-trophic migration characteristics, allowing them to be used as delivery vehicles for successful, targeted treatment of isolated tumors and metastatic malignancies. Preclinical and clinical research were reviewed in this study to discuss using MSC-released OVs as a novel method for the treatment of cancer. [MediaObject not available: see fulltext.] © 2023, The Author(s).
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