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Effects of Long-Term Phenytoin or Phenytoin Plus Ascorbic Acid Administration on Urethane Anesthetic Effect in Rats: A Controlled Study Publisher



Ghazvini MRA1 ; Ghafghazi T2 ; Hajhashemi V2 ; Ani M3
Authors
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Authors Affiliations
  1. 1. Isfahan Center of Public Health Training and Research, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacology, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biochemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Current Therapeutic Research - Clinical and Experimental Published:2002


Abstract

Background: Phenytoin, a widely used anticonvulsant, interacts with many drugs. These interactions may be clinically significant. Objective: This controlled, 31-day study investigated the possible interactions of phenytoin with urethane and ascorbic acid. Methods: Groups of male rats were subjected to long-term oral phenytoin treatment with or without ascorbic acid coadministration. The responsiveness of treated animals to the anesthetic activity of urethane then was investigated by assessing their righting reflexes. Results: Long-term phenytoin treatment resulted in hyporesponsiveness to the urethane anesthetic effect, and this interaction was augmented by ascorbic acid coadministration. Conclusion: Our results indicate that phenytoin interacts with ascorbic acid and urethane in vivo, which may be of clinical and/or experimental importance.
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