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A Comparison Between Osteogenic Index, Gross and Skeletal Abnormalities in the Embryo of Treated Mice With Herbal Lavandula Officinalis and Those With Chemical Phenytoin Antiepileptic Drugs Publisher



Bahmanpour S1 ; Bahaadinie F2 ; Dehkordi AJ3 ; Akhondi F3
Authors
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Authors Affiliations
  1. 1. Anatomy Department, United States
  2. 2. Pharmacology Department, Shiraz University of Medical Sciences, United States
  3. 3. School of Pharmacy Isfahan University of Medical Sciences, Shiraz, Iran

Source: Journal of Applied Animal Research Published:2008


Abstract

Bahmanpour, S., Bahaadinie, F., Dehkordi, A.J. and Akhondi, F. 2008. A comparison between osteogenic index, gross and skeletal abnormalities in the embryo of treated mice with herbal Lavandula officinalis and those with chemical phenytoin antiepileptic drugs. J. Appl. Anim. Res., 33: 85–88. To compare a synthetic drug, phenytoin and an herbal drug, Lavandula officinalis, used as antiepileptic remedy, their teratogenic abnormalities were compared using BalbC mice. The essential oil and phenytoin both reduced the embryo weight, CRL index, length and ossification of femur and tibia and increased the number of abnormal embryos. But these ill effects were more pronounced with phenytoin than with L. officinalis. It can be concluded that herbal remedy L. officinalis is better than synthetic phenytoin with less congenital abnormalities in mice. © 2008 Taylor & Francis Group, LLC.
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