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Unusual Ingenoids From Euphorbia Erythradenia Bioss. With Pro-Apoptotic Effects Publisher Pubmed



Zarei SM1 ; Ayatollahi AM1 ; Ghanadian M2 ; Kobarfard F3 ; Aghaei M4 ; Choudhary MI5 ; Fallahian F6
Authors
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Authors Affiliations
  1. 1. Phytochemistry Research Center and School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacognosy, Isfahan Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshtee University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
  6. 6. Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran

Source: Fitoterapia Published:2013


Abstract

Dichloromethane-acetone extract of Euphorbia erythradenia Bioss., a spurge endemic to the Iran, afforded four novel tetrahydroingenol diterpenes, one new myrsinane type diterpene, and two known triterpenes. Tetrahydroingenoids are novel compounds not only for the double bond reduction but also for their unique hydroxylation pattern at C-11 and C-13. The structures of these compounds were elucidated by spectroscopic methods, and especially 2D NMR measurements. The biological effects of the compounds were done by the MTT and Annexin V-FITC & PI staining assays on different cancer cell lines. The results obtained on EJ-138, CAOV-4, and OVCAR-3 cell lines suggested that tetrahydroingenanes inhibit cell proliferation through apoptosis in cancer cell lines. In conclusion, the new pattern of hydrogenation and hydroxylation of these compounds compared to other ingenoids, along with their apoptosis inducing properties on cancer cells, makes them of great interest for more investigation. © 2013 Elsevier B.V.
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