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Obtusifoliol Related Steroids From Euphorbia Sogdiana With Cell Growth Inhibitory Activity and Apoptotic Effects on Breast Cancer Cells (Mcf-7 and Mda-Mb231) Publisher Pubmed



Aghaei M1 ; Yazdiniapour Z2 ; Ghanadian M3 ; Zolfaghari B2 ; Lanzotti V4 ; Mirsafaee V2
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Dipartimento di Agraria, Universita di Napoli Federico II, Portici, Napoli, Italy

Source: Steroids Published:2016


Abstract

From the aerial parts of Euphorbia sogdiana Popov, obtusifoliol (1) and two related steroids (2–3) have been isolated and characterized along with a known cycloartane derivative (4). The chemical structure of the obtusifoliol-related compounds, obtained by 1D and 2D NMR, and MS measurements, have been determined as: 3β,7α-dihydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-11-one (2) and 3β-hydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-1-one (3). Compound 2 has been previously isolated from Euphorbia chamaesyce while compound 3 was never reported before. The isolated compounds 1–4 were subjected to cytotoxic tests on the breast cancer cells, MCF-7 and MDA-MB231. Further pharmacological tests on the more active compounds 2 and 3 indicated their action to be related to cell growth inhibitory activity and apoptotic effects on the tested cells. © 2016 Elsevier Inc.
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