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Administration of N-Acetylcysteine for Contrast-Induced Acute Kidney Injury; an Updated Mini-Review Publisher



Mirfendereski S1 ; Taghipour M2 ; Yadollahi F3 ; Taghavinejad H4 ; Ahmadnia M4
Authors
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Authors Affiliations
  1. 1. Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Internal Medicine, School of Medicine Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran
  3. 3. Departments of Medicine, Medical School, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Journal of Nephropharmacology Published:2024


Abstract

Contrast-induced acute kidney injury (CI-AKI) is a potential complication of medical imaging procedures that use contrast media. It is important to identify and manage risk factors for contrast-induced nephropathy and to monitor patients for signs of renal damage after contrast administration. N-acetylcysteine (NAC) can prevent CI-AKI through multiple mechanisms of action, including reducing oxidative stress, improving renal hemodynamics, reducing inf lammation, reducing apoptosis and fibrosis, reducing oxidative stress-induced DNA damage, reducing tubular cell injury, and reducing renal tubular cell apoptosis. However, the exact mechanisms of action may vary based on the specific study or context. Further research is needed to fully elucidate the molecular mechanisms of NAC in preventing CI-AKI. © 2024 The Author(s); Published by Society of Diabetic Nephropathy Prevention.
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