Analgesic and Anti-Infammatory Effects of Rosa Damascena Hydroalcoholic Extract and Its Essential Oil in Animal Models



Hajhashemi V¹ ; Ghannadi A² ; Hajiloo M¹ Show Affiliations
Source: Iranian Journal of Pharmaceutical Research Published:2010

Abstract

Extracts obtained from the petals of Rosa damascena (Rosaceae) are used in Iranian folk medicine as remedies for the treatment of some infammatory diseases. In this study the hydroalcoholic extract and essential oil of the plant were investigated for its possible anti-infammatory and analgesic activities. The extract was administered at the doses (p.o.) of 250, 500 and 1000 mg/kg and the doses of essential oil were 100, 200 and 400 μL/kg. The acetic acid-induced writhing response, formalin-induced paw licking time in the early and late phases and light tail fick test were used in mice to assess analgesic activity. For evaluation of anti-infammatory effect carrageenan-induced paw edema served as a valid animal model in rats. The extract signifcantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and also showed potent analgesic effect in both phases of formalin test but not in light tail fick test. In addition, the higher dose of the extract signifcantly (P < 0.05) reduced carrageenan-induced paw edema. Essential oil of the plant at all administered doses failed to show any analgesic or anti-infammatory effect in above mentioned tests. These results provide support for the use of hydroalcoholic extract of Rosa damascena in relieving infammatory pain, and insight into the development of new agents for treating infammatory diseases. © 2010 by School of Pharmacy.