Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evidence for Rosa Damascena Efficacy in Mental Disorders in Preclinical Animal Studies and Clinical Trials: A Systematic Review Publisher Pubmed



Mohamadi N1 ; Pourkorrani MHS2 ; Langarizadeh MA2 ; Ranjbartavakoli M2 ; Sharififar F1, 3 ; Asgary S4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Student Researche Committee, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Pharmacutics Research Center, Neuropharmacology Research insititute, Kerman University of Medical Sciences, Kerman, Iran, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Phytotherapy Research Published:2022


Abstract

The aim of this systematic review was to identify animal preclinical studies and randomized controlled trials that looked at the effects of R. damascena in any form on different mental diseases. Up to September 2021, the online databases of PubMed, Scopus, Embase, Web of Science, and Cochrane trials, as well as SID and MagIran, were searched. This study included 10 animal studies. Except for one research, the rest of the studies confirmed the positive effects of the plant in treatment of mental disorders. A total of 38 studies met the criteria for inclusion. Individuals who have encountered various sorts of mental problems, such as anxiety, sleep disturbance, and depressive disorder, were studied. R. damascena essential oil (EO), essence, extract, and dried plant were used in aromatherapy and oral administration. A decrease in sympathetic nervous system activity, induction of neurotransmitters, induction of nerve growth factors by neurogenesis and synaptogenesis mechanisms, a decrease in prolactin and an increase in noradrenaline, estradiol, and progesterone secretion are some of the mechanisms of action. In general, R. damascena is an effective herb for the treatment of mental disorders. However, further research timing and duration of intervention are needed to extrapolate the findings. © 2022 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Effect of Rosa Damascene Aromatherapy on Anxiety and Sleep Quality in Cardiac Patients: A Randomized Controlled Trial, Complementary Therapies in Clinical Practice (2021)
2. Analgesic and Anti-Infammatory Effects of Rosa Damascena Hydroalcoholic Extract and Its Essential Oil in Animal Models, Iranian Journal of Pharmaceutical Research (2010)
3. Inhibitory Effect of Rosa Damascena Mill Flower Essential Oil, Geraniol and Citronellol on Rat Ileum Contraction, Research in Pharmaceutical Sciences (2013)
4. Effects of Acupressure on Sleep Quality and Anxiety of Patients With Second- or Third-Degree Burns: A Randomized Sham-Controlled Trial, BMC Complementary Medicine and Therapies (2024)
5. Herbal Medications to Manage Insomnia: An Overview of Clinical Trials Using Herbal Treatment for Insomnia, Traditional and Integrative Medicine (2022)
6. Evaluation of Antianxiety and Sedative Effects of Essential Oil of Ducrosia Anethifolia in Mice, Clinics (2010)
7. Lavender and Dodder Combined Herbal Syrup Versus Citalopram in Major Depressive Disorder With Anxious Distress: A Double-Blind Randomized Trial, Journal of Integrative Medicine (2020)
8. Sulfoquinovosyl Oleoyl Palmitoyl Glycerol (Sqdg) and Hexane Extract of Sargassum Plagyophylum Prevent Depression Induced by Dexamethasone or Stress in Mice, Journal of HerbMed Pharmacology (2021)
Experts (# of related papers)
View all Related Experts
Mohammad Rabbani (8)
Valiollah Hajhashemi (6)
Other Related Docs
9. Evaluation of the Anxiolytic Effect of Nepeta Persica Boiss. in Mice, Evidence-based Complementary and Alternative Medicine (2008)
10. Application of Some Herbal Medicine Used for the Treatment of Osteoarthritis and Chondrogenesis, Traditional and Integrative Medicine (2020)
11. Anti-Nociceptive and Anti-Inflammatory Effects of Ferulago Angulata, Immunopathologia Persa (2020)
12. Saffron (Crocus Sativus) As a Middle East Herb: Traditional and Modern Medicinal Applications, Ancient and Traditional Foods, Plants, Herbs and Spices used in the Middle East (2023)
13. The Effect of Rosa Damascena Extract on Blood Glucose and Insulin Levels in Diabetic Rats, Journal of Isfahan Medical School (2020)
14. Anxiolytic Effects of Lippia Citriodora in a Mouce Model of Anxiety, Research in Pharmaceutical Sciences (2018)
15. Comparative Study of Anti-Diabetic Effects of Insulin, Epigenin and Salvia Mirzayanii Extract in Streptozotocin-Induced Diabetic Male Rats, Indian Journal of Biochemistry and Biophysics (2023)
16. The Effects of Wheat Germ Consumption on Mental Health and Brain-Derived Neurotrophic Factor in Subjects With Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial, Nutritional Neuroscience (2022)
17. Lavender Essential Oil Improved Depressive Behavior in Mice After Interferon-Α Administration But Not After Cyclosporine a Administration, Bulletin of Pharmaceutical Sciences. Assiut (2023)
18. Collection and Assessment of Traditional Medicinal Plants Used by the Indigenous People of Dastena in Iran, Journal of HerbMed Pharmacology (2016)
19. Portulaca Oleracea Seeds Extract Does Not Prevent Dexamethasone-Induced Hypertension in Rats, Journal of HerbMed Pharmacology (2018)
20. Phytochemical Analysis of Some Plants From Lamiaceae Family Frequently Used in Folk Medicine in Aligudarz Region of Lorestan Province; [Lorestan Ilinin Aligudarz Bolgesinde Halk Ilaci Olarak Sikca Kullanilan Lamiaceae Familyasindan Bazi Bitkilerin Fitokimyasal Analizi], Marmara Pharmaceutical Journal (2017)
21. Efficacy of Herbal Combination of Sedge, Saffron, and Astragalus Honey on Major Neurocognitive Disorder, Journal of Research in Medical Sciences (2018)
22. Nigella Sativa Extract in the Treatment of Depression and Serum Brain-Derived Neurotrophic Factor (Bdnf) Levels, Journal of Research in Medical Sciences (2022)
23. Therapeutic Potential of Berries in Age-Related Neurological Disorders, Frontiers in Pharmacology (2024)
24. Hypnotic Effect of Salvia Reuterana Boiss for Treatment of Insomnia, Journal of Medicinal Plants (2013)
25. Anxiolytic Effects of Stachys Lavandulifolia Vahl on the Elevated Plus-Maze Model of Anxiety in Mice, Journal of Ethnopharmacology (2003)
26. Black Cumin Seed Essential Oil, As a Potent Analgesic and Antiinflammatory Drug, Phytotherapy Research (2004)
27. Hypnotic Effect of Coriandrum Sativum, Ziziphus Jujuba, Lavandula Angustifolia and Melissa Officinalis Extracts in Mice, Research in Pharmaceutical Sciences (2015)
28. The Effect of Auriculotherapy on Stress, Anxiety, and Depression in Ms Patients: A Double Blind Randomized Clinical Control Trial (Parallel Design), Acta Medica Mediterranea (2018)
29. Anti-Inflammatory Effect of Volatile Oil and Hydroalcoholic Extract of Rosa Damascena Mill. on Acetic Acid-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2015)
30. Evaluation of Anxiolytic and Sedative Effect of Essential Oil and Hydroalcoholic Extract of Ocimum Basilicum L. and Chemical Composition of Its Essential Oil, Research in Pharmaceutical Sciences (2015)
31. Inhibitors of Α-Synuclein Fibrillation and Oligomer Toxicity in Rosa Damascena: The All-Pervading Powers of Flavonoids and Phenolic Glycosides, ACS Chemical Neuroscience (2020)
32. The Antidepressant Effects of Lavender (Lavandula Angustifolia Mill.): A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Complementary Therapies in Medicine (2021)
33. Plant-Based Eating Pattern and Psychological Symptoms: A Cross-Sectional Survey Among Patients With Migraine, Nutritional Neuroscience (2025)
34. Sedative and Hypnotic Effects of Iranian Traditional Medicinal Herbs Used for Treatment of Insomnia, EXCLI Journal (2011)
35. Anxiolytic Effect of Flowers of Salix Aegyptiaca L. in Mouse Model of Anxiety, Journal of Complementary and Integrative Medicine (2010)
36. Bioactivity Guided Isolation of Apigenin From Stachys Lavandulifolia Vahl. in Mice With Anxiolytic Effects, Journal of HerbMed Pharmacology (2018)
37. The Relationship Between a Plant-Based Diet and Mental Health: Evidence From a Cross-Sectional Multicentric Community Trial (Lipokap Study), PLoS ONE (2023)
38. Flaxseed Oil Supplementation on Severity of Depression and Brain-Derived Neurotrophic Factor: A Randomized, Double Blind Placebo Controlled Clinical Trial, International Journal of Food Properties (2020)
39. Effect of Rosa Damascena Mill. Flower Extract on Rat Ileum, Research in Pharmaceutical Sciences (2013)
40. From Kitchen to Clinic: Pharmacotherapeutic Potential of Common Spices in Indian Cooking in Age-Related Neurological Disorders, Frontiers in Pharmacology (2022)
41. Ginseng Treatment Improves the Sexual Side Effects of Methadone Maintenance Treatment, Psychiatry Research (2019)
42. Novel Effects of Rosa Damascena Extract on Patients With Neurocognitive Disorder and Depression: A Clinical Trial Study, International Journal of Preventive Medicine (2018)
43. Effects of Herbal Medicine on Memory Impairment in Electroconvulsive Therapy, Journal of Research in Medical Sciences (2012)
44. Plant-Derived Medicines for Neuropathies: A Comprehensive Review of Clinical Evidence, Reviews in the Neurosciences (2019)
45. The Effects of Alcoholic Extract of Saffron (Crocus Satious L.) on Mild to Moderate Comorbid Depression-Anxiety, Sleep Quality, and Life Satisfaction in Type 2 Diabetes Mellitus: A Double-Blind, Randomized and Placebo-Controlled Clinical Trial, Complementary Therapies in Medicine (2018)
46. Medicinal Plants and Their Isolated Phytochemicals for the Management of Chemotherapy-Induced Neuropathy: Therapeutic Targets and Clinical Perspective, DARU, Journal of Pharmaceutical Sciences (2019)
47. Changes in Polyphenolic Composition, Physiological Characteristics, and Yield-Related Traits of Moshgak (Ducrosia Anethifolia Boiss.) Populations in Response to Drought Stress, Protoplasma (2023)
48. Efficacy of Memoral Herbal on Prevention of Electroconvulsive Therapy-Induced Memory Impairment in Mood Disorder Patients (Isfahan - Iran 2011), International Journal of Preventive Medicine (2012)