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Poly (Butylene Adipate-Co-Terephthalate) Electrospun Nanofibers Loaded With 5-Fluorouracil and Curcumin in Treatment of Colorectal Cancer Cells Publisher



Varshosaz J1 ; Jajaniannajafabadi A2 ; Soleymani A1 ; Khajavinia A1
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biotechnology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Polymer Testing Published:2018


Abstract

Objectives In the present study the electrospinning technique was used for production of poly (butylene adipate-co-terephthalate) nanofibers loaded with 5-fluorouracil (5-FU) and curcumin in treatment of colorectal cancer. Methods Studied processing and formulation variables included: voltages, polymer concentration, injection rate, distances between the needle tip and the collector plate, concentration of 5-FU, curcumin, and the polymer on the nanofiber features. The cytotoxicity of the nanofibers was studied on the HT29 colorectal cancer cells. Results The results showed that changes in the drug release profiles were not significant but diameter of the nanofibers and drug entrapment percent were statistically affected by the polymer concentration and its injection rate. Cell culture results showed that the nanofibers loaded with the combination of the drugs had higher cytotoxicity against HT29 cells in comparison with the single-drug-loaded nanofibers and the drug solutions. Conclusion Ecoflex nanofibers loaded with 5-FU and curcumin may be useful in topical application in colorectal cancers. © 2017 Elsevier Ltd
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