Enoxaparin Initiation After Chronic Subdural Haematoma Evacuation: A Randomized Clinical Trial on Timing and Outcomes Publisher



Shafiei M¹ ; Sabouri M¹ ; Aminmansour B¹ ; Mahmoodkhani M¹ ; Sourani A¹ ; Salehi I¹ ; Foroughi M² Show Affiliations
Source: Surgical Practice Published:2023

Abstract

Aim: Patients with chronic subdural haematoma (CSDH) are at a significant risk for venous thromboembolism (VTE). Surgeons should weigh the advantages versus disadvantages of anticoagulants in the postoperative period. Patients and Methods: This study was a randomized clinical trial conducted in Isfahan, Iran, from May 2016 to April 2021. Patients with CSDH eligible for bur-hole craniostomy were primarily enrolled. All of them underwent bilateral lower limb Doppler ultrasonography (DUS) for deep venous thrombosis (DVT) screening. The patients were randomized into the case (n = 66, enoxaparin initiation 24 h after operation) and control (n = 70, enoxaparin initiation 72 h after operation) groups. Routine postoperative brain computed tomography scans were obtained 1 and 3 days after surgery. A second DUS was performed 96 h after operation to screen newly developed venous thrombosis; P value <.05 was defined significant. Results: A total of 73 patients (59.8%) were female and 49 (40.2%) were male. The mean age was 65.1 ± 10.19 years; 9.9% of the patients had previously used antiplatelets. One patient had asymptomatic preoperative DVT. The mean values for enoxaparin dosage were 40.4918 ± 5.43 mg/day. Postoperative DVT or rebleeding prevalence was 0% in both groups. The mean follow-up duration was 19.139 ± 2.2 months. Long-term recurrence rate was 2.4% (n = 3). Postoperative pneumocephalus was associated with a higher recurrence rate (P =.031). Conclusion: In terms of VTE chemoprophylaxis, following bur-hole craniostomy for CSDH, enoxaparin will effectively prevent VTE development without any clinically significant rebleeding. © 2023 College of Surgeons of Hong Kong.