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Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial Publisher Pubmed



Pahlavani N1, 2, 3 ; Malekahmadi M4, 5 ; Sedaghat A6 ; Rostami A7 ; Alkadir OKA8 ; Taifi A9 ; Ranjbar G3 ; Sahebkar A10, 11 ; Abdelbasset WK12, 13 ; Beigmohammadi MT4 ; Mir M14 ; Bagheri Moghaddam A14, 15 ; Tabesh H16 ; Sadeghi O17 Show All Authors
Authors
  1. Pahlavani N1, 2, 3
  2. Malekahmadi M4, 5
  3. Sedaghat A6
  4. Rostami A7
  5. Alkadir OKA8
  6. Taifi A9
  7. Ranjbar G3
  8. Sahebkar A10, 11
  9. Abdelbasset WK12, 13
  10. Beigmohammadi MT4
  11. Mir M14
  12. Bagheri Moghaddam A14, 15
  13. Tabesh H16
  14. Sadeghi O17
  15. Gholizadeh Navashenaq J18
  16. Firouzi S3
  17. Fathi Najafi M19
  18. Safarian M3
  19. Ghayourmobarhan M20, 21
Show Affiliations
Authors Affiliations
  1. 1. Health Sciences Research Center, Torbat Heydarieh University of Medical Sciences, Torbat Heydarieh, Iran
  2. 2. Department of Clinical Biochemistry and Nutrition, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  3. 3. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Anesthesiology and Intensive Care Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Cardiac Anesthesia Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Internal Medicine, Faculty of General Medicine, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia
  8. 8. Al-Nisour University College, Baghdad, Iraq
  9. 9. Al-Manara College for Medical Sciences, Al-Amarah, Iraq
  10. 10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia
  13. 13. Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt
  14. 14. Department of Anesthesiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  15. 15. Department of Internal Medicine and Critical Care, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  16. 16. Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  17. 17. Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  18. 18. Non-Communicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  19. 19. Department of Veterinary Research and Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, Iran
  20. 20. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  21. 21. Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Complementary Medicine Research Published:2022


Abstract

Background and Objective: The present study aimed to investigate the effects of propolis and melatonin supplementation on inflammation, clinical outcomes, and oxidative stress markers in patients with primary pneumosepsis. Materials and Methods: This pilot randomized controlled trial was conducted on 55 patients with primary pneumosepsis who were randomly assigned to the intervention and control groups. In the three intervention groups, the patients received propolis alone (1,000 mg/day), propolis (1,000 mg/day) plus melatonin (20 mg/day), and melatonin alone (20 mg/day). The control group received placebo. The inflammatory and oxidative stress markers as well as clinical outcomes were evaluated before and after the intervention, and the 28-day survival rate was also recorded. Results: After the intervention, the combination of propolis and melatonin significantly reduced interleukin-6 (-55.282 pg/mL) and C-reactive protein (-21.656 mg/L) levels, while increasing gavage intake (326.680 mL/day) and improving some clinical outcomes (APACHE II, SOFA, and NUTRIC scores) compared to the control group. However, no significant difference was observed between the groups in terms of oxidative stress and hematological indices. In addition, there was no significant difference in the 28-day survival rate between the groups (p = 0.07). Conclusion: Supplementation with propolis and melatonin may improve clinical outcomes by reducing inflammation. Further investigations are required to confirm these findings. © 2022 S. Karger AG. All rights reserved.
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