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Genetics of Familial Combined Hyperlipidemia (Fchl) Disorder: An Update Publisher Pubmed



Taghizadeh E1, 2 ; Farahani N3 ; Mardani R4 ; Taheri F5 ; Taghizadeh H2 ; Gheibihayat SM6
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  3. 3. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran
  5. 5. Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
  6. 6. Department of Medical Biotechnology, School of Medicine, Shahid Sadoughi University of Medical Sciences, P.O. Box: 91735-951, Yazd, Iran

Source: Biochemical Genetics Published:2022


Abstract

Familial combined hyperlipidemia (FCHL) is one of the most common familial lipoprotein disorders of the lipoproteins, with a prevalence of 0.5% to 2% in different populations. About 10% of these patients suffer from cardiovascular disease and this number is increased by up to 11.3% in the young survivors of myocardial infarction and by 40% among all the survivors of myocardial infarction. Although initially thought to be that FCHL has an inheritance pattern of monogenic, the disease’s etiology is still not fully understood and it appears that FCHL has a complex pattern related to genetic variants, environmental factors, and lifestyles. Two strategies have been used to identify its complex genetic background: candidate gene and the linkage approach, which have yielded an extensive list of genes associated with FCHL with a variable degree of scientific evidence. Until now, more than 30 different genetic variants have been identified related to FCHL. In this study, we aimed to review the individual genes that have been described in FCHL and how these genes and variants can be related to the current concept of metabolic pathways resulting in familial combined hyperlipidemia. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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