Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Biochemical and Histopathological Study of the Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Cornelian Cherry (Cornus Mas L.) in Alloxan-Induced Diabetic Rats Publisher Pubmed



Asgary S2 ; Rafieiankopaei M3 ; Shamsi F3 ; Najafi S4 ; Sahebkar A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
  2. 2. Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Physiology Research Center, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran

Source: Journal of Complementary and Integrative Medicine Published:2014


Abstract

Background: Anthocyanins are phytochemicals with a multitude of pharmacological actions including anti-diabetic and anti-hyperlipidemic effects. This study was undertaken to evaluate the anti-hyperglycemic and antihyperlipidemic effects of cornelian cherry (Cornus mas L., CM) fruits - that are rich in anthocyanins and known to have medicinal properties- in alloxan-induced diabetic rats. Methods: Twenty-eight adult male rats were randomly assigned to four groups of seven animals each: non-diabetic control, diabetic control, glibenclamide-treated (0.6 mg/kg/day; 4 weeks) and CM fruit-treated (2 g/day; 4 weeks) group. Diabetes was induced by a single injection of alloxan (120 mg/kg). Fasting serum levels of glucose, total cholesterol (TC), low- (LDL-C) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), aspartate (AST) and alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured at the end of study period. Results: Diabetic rats had significantly elevated levels of serum glucose, LDL-C, TG, AST, ALP and ALT and decreased levels of HDL-C compared to the non-diabetic group (p < 0.05). Treatment with either glibenclamide or CM counterbalanced the above-mentioned abnormalities. The effects of CM were comparable to those of glibenclamide at the doses tested in this study. Serum glucose, TG, ALP and HDL concentrations in the normal group were significantly changed compared to the diabetic control group (p < 0.05). There were no significant changes in evaluated biochemical parameters between the glibenclamide and CM groups with normal group. Histopathological examinations revealed a less severe hepatic portal inflammation in the CM-treated vs. other study groups. Conclusions: Dietary supplementation with CM fruits effectively prevents the development of diabetes mellitus, dyslipidemia and hepatic inflammation in alloxan-induced diabetes.
Related Docs
View other Related Docs
1. Effects of Cornus Mas L. on Blood Glucose, Insulin and Histopathology of Pancreas in Alloxan-Induced Diabetic Rats, Journal of Isfahan Medical School (2011)
2. Evaluation of the Effects of Cornus Mas L. Fruit Extract on Glycemic Control and Insulin Level in Type 2 Diabetic Adult Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Evidence-based Complementary and Alternative Medicine (2015)
3. Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Vaccinium Myrtillus Fruit in Experimentally Induced Diabetes (Antidiabetic Effect of Vaccinium Myrtillus Fruit), Journal of the Science of Food and Agriculture (2016)
4. Hypoglycaemic and Hypolipidemic Effects of Pumpkin (Cucurbita Pepo L.) on Alloxan-Induced Diabetic Rats, African Journal of Pharmacy and Pharmacology (2011)
5. Preventive Effect of Pumpkin (Cucurbita Pepo L.) on Diabetic Index and Histopathology of Pancreas in Alloxan-Induced Diabetes in Rats, Journal of Isfahan Medical School (2011)
6. Investigation of the Lipid-Modifying and Antiinflammatory Effects of Cornus Mas L. Supplementation on Dyslipidemic Children and Adolescents, Pediatric Cardiology (2013)
7. Antioxidant Plants and Diabetes Mellitus, Journal of Research in Medical Sciences (2015)
8. Effect of Ethanolic Extract of Juglans Regia L. on Blood Sugar in Diabetes-Induced Rats, Journal of Medicinal Food (2008)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (27)
Mustafa Ghanadian (7)
Other Related Docs
9. Effects of Methanolic and Butanolic Fractions of Allium Elburzense Wendelbo Bulbs on Blood Glucose Level of Normal and Stz-Induced Diabetic Rats, Research in Pharmaceutical Sciences (2012)
10. Antidiabetic Effect of Hydroalcoholic Extract of Carthamus Tinctorius L. in Alloxan-Induced Diabetic Rats, Journal of Research in Medical Sciences (2012)
11. Effect of Hydroalcoholic and Buthanolic Extract of Cucumis Sativus Seeds on Blood Glucose Level of Normal and Streptozotocin-Induced Diabetic Rats, Iranian Journal of Basic Medical Sciences (2011)
12. The Effects of Cornelian Cherry on Atherosclerosis and Atherogenic Factors in Hypercholesterolemic Rabbits, Journal of Medicinal Plants Research (2011)
13. Effects of Salvia Mirzayanii Extract Administration on Hyperglycemia Improvement in Diabetic Rats: The Role of Glut4, Pepck and G6pase Genes, Heliyon (2024)
14. Antihyperglycemic and Antihyperlipidemic Effect of Chronic Administration of Hesperetin in Diabetic Rats, Journal of Babol University of Medical Sciences (2010)
15. Atherosclerosis: Process, Indicators, Risk Factors and New Hopes, International Journal of Preventive Medicine (2014)
16. The Effects of Aqueous Extract of Alfalfa on Blood Glucose and Lipids in Alloxan-Induced Diabetic Rats, Interventional Medicine and Applied Science (2015)
17. Effect of the Hydroalcoholic Extract and Juice of Prunus Divaricata Fruit on Blood Glucose and Serum Lipids of Normal and Streptozotocin Induced Diabetic Rats, Research in Pharmaceutical Sciences (2014)
18. Comparative Study of Anti-Diabetic Effects of Insulin, Epigenin and Salvia Mirzayanii Extract in Streptozotocin-Induced Diabetic Male Rats, Indian Journal of Biochemistry and Biophysics (2023)
19. The Protective Effects of Ziziphus Vulgaris L. Fruits on Biochemical and Histological Abnormalities Induced by Diabetes in Rats, Journal of Complementary and Integrative Medicine (2014)
20. Effects of Berberis Vulgaris Fruit Extract on Oxidative Stress Status in the Kidney and Liver of Diabetic Rats, Journal of Complementary and Integrative Medicine (2024)
21. Protective and Therapeutic Effects of Phoenix Dactylifera Leaf Extract on Pancreatic Β-Cells and Diabetic Parameters in Streptozotocin-Induced Diabetic Rats, Comparative Clinical Pathology (2020)
22. Effects of Hydroalcoholic Extract of Juglans Regia Leaves on Activity of Ast and Alt Enzymes in Alloxan- Induced Diabetic Rats, Pharmaceutical Sciences (2009)
23. Effect of the Administration of Solanum Nigrum Fruit on Prevention of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats, Pharmacognosy Research (2017)
24. Regulation of Apolipoprotein B by Natural Products and Nutraceuti-Cals: A Comprehensive Review, Current Medicinal Chemistry (2021)
25. Effects of Aqueous Extract of Alfalfa on Hyperglycemia and Dyslipidemia in Alloxan-Induced Diabetic Wistar Rats, Interventional Medicine and Applied Science (2016)
26. Allium Affine Extract Improves Dexamethasone-Induced Hyperlipidemia in Rats, Research Journal of Pharmacognosy (2023)
27. Endothelium-Dependent Effect of Sesame Seed Feeding on Vascular Reactivity of Streptozotocin-Diabetic Rats: Underlying Mechanisms, Iranian Journal of Pharmaceutical Research (2013)
28. Isolation of Two Steroidal Saponins With Antileishmanial Activity From Allium Giganteum L., Research in Pharmaceutical Sciences (2024)
29. Effect of Long-Term Administration of Oral Magnesium Sulfate and Insulin to Reduce Streptozotocin-Induced Hyperglycemia in Rats: The Role of Akt2 and Irs1 Gene Expressions, Biological Trace Element Research (2019)
30. Hypolipidemic Activity of Allium Porrum L. in Cholesterol-Fed Rabbits, Journal of Medicinal Food (2006)
31. Antioxidant Activity in Some in Vitro Oxidative Systems of the Essential Oils From the Fruit and the Leaves of Platycladus Orientalis, Journal of Essential Oil Research (2011)
32. The Effect of Purslane Seeds on Biomarkers of Oxidative Stress in Diabetic Patients: A Randomized Controlled Cross-Over Clinical Trial, International Journal of Preventive Medicine (2015)
33. Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review, Advances in Experimental Medicine and Biology (2021)
34. Effects of Eicosapentaenoic Acid and Vitamin C on Glycemic Indices, Blood Pressure, and Serum Lipids in Type 2 Diabetic Iranian Males, Journal of Research in Medical Sciences (2011)
35. A Survey on Microbial Quality of Herbal Distillates in Isfahan, Central of Iran, Studia Universitatis Vasile Goldis Arad, Seria Stiintele Vietii (2014)
36. Effects of Cucurbita Ficifolia Intake on Type 2 Diabetes: Review of Current Evidences, Shiraz E Medical Journal (2014)
37. Anti-Diabetic Effects of Walnut Oil on Alloxan-Induced Diabetic Rats, African Journal of Pharmacy and Pharmacology (2011)
38. The Effects of Berberis Integerrima Fruit Extract on Glycemic Control Parameters in Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial, Evidence-based Complementary and Alternative Medicine (2021)
39. Effects of Probiotic Soy Milk Fermented by Lactobacillus Plantarum A7 (Kc 355240) Added With Cuminum Cyminum Essential Oil on Fasting Blood Glucose Levels, Serum Lipid Profile and Body Weight in Diabetic Wistar Rats, International Journal of Preventive Medicine (2020)
40. Dietary Phytochemical Index and Its Relationship With Diabetic Sensorimotor Polyneuropathy: A Case-Control Study, Scientific Reports (2024)
41. Chronic Administration of Daidzein, a Soybean Isoflavone, Improves Endothelial Dysfunction and Attenuates Oxidative Stress in Streptozotocin- Induced Diabetic Rats, Phytotherapy Research (2013)
42. Effect of Fenugreek Seeds on Blood Glucose and Lipid Profiles in Type 2 Diabetic Patients, International Journal for Vitamin and Nutrition Research (2009)
43. Antioxidant Effect of Turmeric and Saffron on the Oxidation of Hepatocytes, Ldl and Non-Enzymatic Glycation of Hemoglobin, Journal of Medicinal Plants (2005)
44. Protective Effect of Quercetin on Alteration of Antioxidant Genes Expression and Histological Changes in the Dental Pulp of the Streptozotocin-Diabetic Rats, Archives of Oral Biology (2021)
45. The Effects of Concurrent Hydroalcoholic Extract of Amaranthus Caudatus L. and Hypericum Perforatum L. of Fatty Streak Formation in Hypercholesterolemic Animals, African Journal of Pharmacy and Pharmacology (2011)
46. Inflammatory Biomarkers, Antioxidant Enzyme Activities, and Oxidative Stress in Iranian Male Patients With Type 2 Diabetes Mellitus: Effects of Eicosapentaenoic Acid and Vitamin C Supplementation, Journal of Research in Medical Sciences (2012)
47. Effects of the Hydro-Alcoholic Extract of Clove (Dianthus Deltoides) on Inflammation and Pain Response Using the Xylene Test and Hot Plate Test in Mice, Journal of Babol University of Medical Sciences (2015)
48. Herbs With Anti-Lipid Effects and Their Interactions With Statins As a Chemical Antihyperlipidemia Group Drugs: A Systematic Review, ARYA Atherosclerosis (2015)
49. A Systematic Review on Safety and Drug Interaction of Herbal Therapy in Hyperlipidemia: A Guide for Internist, Acta Biomedica (2015)
50. New Concepts in Nutraceuticals As Alternative for Pharmaceuticals, International Journal of Preventive Medicine (2014)