Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Exploring the Potent Antifungal Activity of Mazuj and Ghalghaf Gall Extracts Against Three Candida Species and Conducting Compositional and Characterization Analysis of Their Extracts Using Hplc-Dad and Lc-Esi-Ms/Ms Publisher



Chaharmiridokhaharani S1 ; Tavakoli M2 ; Tarahi MJ3 ; Rashidipour M4 ; Yarahmadi M5 ; Sepahvand A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Agricultural Research, Education and Extension Organization (AREEO), Lorestan Agricultural & Natural Resources Research Centre, Khorramabad, Iran
  3. 3. Department of Epidemiology & Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  5. 5. Department of Medical Parasitology and Mycology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Source: Journal of Medicinal Plants and By-Products Published:2024


Abstract

The development of novel antifungal agents has become increasingly crucial according to the antifungal resistance of Candida species. Using natural product compounds as alternatives to conventional drugs is being explored to advance a more effective treatment for C. infections. This study aims to determine biological activity and the chemical compound characterization of the aqueous and acetonic extracts obtained from Mazuj and Ghalghaf galls of Quercus infectoria. After the galls extraction, the extracts' antifungal properties were investigated using an agar well diffusion method and concentrations of minimum fungicidal (MFCs) and minimum inhibitory (MICs). We utilized the ABTS and MTT methods to determine gall extracts' antioxidant and cytotoxic properties. Additionally, we identified the chemical compounds present in the extracts using LC-ESI-MS/MS and HPLC-DAD. The study results showed that both acetonic and aqueous extracts of Ghalghaf and Mazuj galls were efficient against species of three fungi species such as C. albicans, C. glabrata, and C. krusei, and in particular, the acetonic Mazuj extract demonstrated the highest effectiveness as an antifungal. Furthermore, the Mazuj extract exhibited elevated levels of total phenolics and the most increased antioxidant activity. Moreover, LC-ESI-MS/MS and HPLC-DAD analysis indicated the presence of various phenolic compounds in the extracts, including gallic acid, methyl gallate, and ellagic acid. Overall, the study's findings suggest that Mazuj and Ghalghaf galls demonstrate promising antifungal and antioxidant properties, where these compounds could potentially be used to develop natural and safe antifungal agents. © 2012 Iranian Society of Medicinal Plants. All rights reserved.
Related Docs
View other Related Docs
1. Antifungal Activity of Almond (Prunus Amygdalus) Hull Extracts Against Clinical Isolates of Candida Albicans, Current Medical Mycology (2024)
2. A Review of the Antifungal Properties of Medicinal Herbs, Journal of Isfahan Medical School (2015)
3. Antifungal Activity of Zingiber Officinale Rosc. Essential Oil Against Fluconazole Resistant Vaginal Isolates of Candida Albicans, Journal of Medicinal Plants (2007)
4. Loading Ferulic Acid Into Β-Cyclodextrin Nanosponges; Antibacterial Activity, Controlled Release and Application in Pomegranate Juice As a Copigment Agent, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2022)
5. Synergistic Activity Between Echinophora Platyloba Dc Ethanolic Extract and Azole Drugs Against Clinical Isolates of Candida Albicans From Women Suffering Chronic Recurrent Vaginitis, Journal de Mycologie Medicale (2014)
6. Antifungal Activity of Anethum Graveolens Extract and Atrovastatin Against Candida Species Compared to Fluconazole, Journal of Isfahan Medical School (2015)
7. Antifungal Effect of Atorvastatin Against Candida Species in Comparison to Fluconazole and Nystatin, Medicine and Pharmacy Reports (2019)
8. Antibacterial, Antifungal and Cytotoxic Evaluation of Some New Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2012)
Experts (# of related papers)
View all Related Experts
Rasoul Mohammadi (14)
Parvin Dehghan (5)
Other Related Docs
9. In Vitro Activities of Six Antifungal Drugs Against Candida Glabrata Isolates: An Emerging Pathogen, Jundishapur Journal of Microbiology (2016)
10. Anti-Pseudomonas Activity of Essential Oil, Total Extract, and Proanthocyanidins of Pinus Eldarica Medw. Bark, Research in Pharmaceutical Sciences (2016)
11. Antibacterial, Antifungal and Cytotoxic Evaluation of Some New 2,3-Disubstituted 4(3H)-Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2012)
12. In Vitro Antifungal Susceptibility Profile of Iranian Fusarium Isolates: Emphasising on the Potent Inhibitory Effect of Efinaconazole Compared to Other Drugs, Mycoses (2023)
13. Amino Acid Substitutions in Erg11p of Azole-Resistant Candida Glabrata: Possible Effective Substitutions and Homology Modelling, Journal of Global Antimicrobial Resistance (2016)
14. Bioassay-Guided Isolation in Salvia Abrotanoides Karel. Stem Based on Its Anti-Fungal and Anti-Trichomonas Activity, Research in Pharmaceutical Sciences (2023)
15. Evaluation of the Antifungal Effect of Fluconazole Separately and With Coriander Essential Oil on Candida Species Isolated From the Mouth of Hiv-Positive Individuals, Scientific Journal of Kurdistan University of Medical Sciences (2023)
16. Antifungal Activity of Cinnamomum Zeylanicum Essential Oil Against Clinical Isolates of Aspegillus, Journal of Medicinal Plants (2010)
17. Antifungal Activity of Ferula Assa- Foetida Against Clinical Agents of Mucormycosis, Journal of Isfahan Medical School (2009)
18. Docking Study, Synthesis and Antimicrobial Evaluation of Some Novel 4-Anilinoquinazoline Derivatives, Research in Pharmaceutical Sciences (2017)
19. Antibacterial Effect of Allium Ampeloprasum and Allium Porrum Extracts on Staphylococcus Aureus and Pseudomonas Aeruginosa, Journal of Pharmacopuncture (2023)
20. The Effects of Nutraceuticals and Herbal Medicine on Candida Albicans in Oral Candidiasis: A Comprehensive Review, Advances in Experimental Medicine and Biology (2021)
21. Caspofungin-Non-Susceptible Candida Orthopsilosis Isolated From Onychomycosis in Iran, Iranian Journal of Public Health (2017)
22. The Anticancer and Antibacterial Potential of Bioactive Secondary Metabolites Derived From Bacterial Endophytes in Association With Artemisia Absinthium, Scientific Reports (2023)
23. Multicenter Identification and Antifungal Susceptibility Patterns of Candida Species Isolated From Clinical Samples, Jundishapur Journal of Microbiology (2017)
24. In-Vivo Efficiency of the Novel Azole Compounds (Attaf-1 and Attaf-2) Against Systemic Candidiasis in a Murine Model, Journal of Medical Mycology (2023)
25. Phytochemical, Antioxidant and Antimicrobial Activity of the Essential Oil From Flowers and Leaves of Achillea Millefolium Subsp. Millefolium, Journal of Essential Oil-Bearing Plants (2017)
26. Chemical Composition, Antioxidant Properties, and Antimicrobial Activity of Ferula Assa-Foetida L. Essential Oil Against Pathogenic Bacteria, Chemical Methodologies (2024)
27. In Vitro Antifungal Susceptibility Pattern of Candida Species Isolated From Gastroesophageal Candidiasis, Gastroenterology and Hepatology from Bed to Bench (2021)
28. Study of Aqueous and Alcoholic Extract of the Melissa Officinalis Effect on Candida Albicans, Candida Glabrata and Candida Krusei, Journal of Military Medicine (2017)
29. Evaluation of Three Plant Extracts Against Biofilm Formation and Expression of Quorum Sensing Regulated Virulence Factors in Pseudomonas Aeruginosa, Pakistan Journal of Pharmaceutical Sciences (2017)
30. Antifungal Susceptibility Testing of Candida Species Isolated From the Immunocompromised Patients Admitted to Ten University Hospitals in Iran: Comparison of Colonizing and Infecting Isolates, BMC Infectious Diseases (2017)
31. Antimicrobial Activities of Phenolic and Non-Phenolic Fractions of Inula Viscosa (L) Extract, Journal of Biologically Active Products from Nature (2011)
32. Cross-Sectional Study of Candidemia From Isfahan, Iran: Etiologic Agents, Predisposing Factors, and Antifungal Susceptibility Testing, Journal of Research in Medical Sciences (2021)
33. Antioxidant Activity of Methanolic Leaf Extract of Moringa Peregrina (Forssk.) Fiori, Research in Pharmaceutical Sciences (2012)
34. In Vitro Activity of Juglone (5-Hydroxy-1,4-Naphthoquinone) Against Both Fluconazole-Resistant and Susceptible Candida Isolates; [Actividad in Vitro De Juglona (5-Hidroxi-1,4-Naftoquinona) Contra Aislamientos De Candida Resistentes Y Sensibles a Fluconazol], Revista Iberoamericana de Micologia (2022)
35. Antifungal Effect of Atorvastatin in Comparison With Fluconazole on Candida Species Isolated From Patients Undergoing Head‑And‑Neck Radiotherapy, Dental Research Journal (2024)
36. Antifungal Effect of Echinophora Platyloba Essence Against the Candida Species Isolated From Vulvovaginal Candidiasis, Compared With Fluconazole, Journal of Isfahan Medical School (2014)