Synthesis and Calcium Antagonist Activity of 1,4-Dihydropyridines Containing Phenylaminoimidazolyl Substituents

Synthesis and Calcium Antagonist Activity of 1,4-Dihydropyridines Containing Phenylaminoimidazolyl Substituents Publisher Pubmed

Zarghi A¹ ; Sadeghi H² ; Fassihi A² ; Faizi M³ ; Shafiee A⁴

Show Affiliations

1. Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Shaheed Beheshti Univ. of Med. Sci., Tehran, Iran
2. Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Isfahan Univ. of Medical Sciences, Isfahan, Iran
3. Department of Pharmacology, Faculty of Pharmacy, Shaheed Beheshti Univ. of Med. Sci., Kerman, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Univ. of Medical Sciences, Tehran 14174, P.O. Box 14155/6451, Iran

Source: Farmaco Published:2003

Abstract

Alkyl ester analogues of nifedipine, in which the ortho-nitrophenyl group at position 4 is replaced by 2-methylthio-1-phenylamino-5-imidazolyl substituent, were synthesized and evaluated as calcium-channel antagonists using the high K+ contraction of guinea-pig ileal longitudinal smooth muscle. The results for the symmetrical esters showed that in the series of alkyl esters increasing the length of methylene chain in C-3 and C-5 ester substituents for more than two methylene units decreases activity. In the phenylalkyl ester series increasing the length of methylene chain also decreases activity. The results demonstrate that most of the compounds had similar activity to the reference drug nifedipine. In addition, two compounds, 5b and 5f were more active than the nifedipine. © 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

2. New Diterpene Polyester and Phenolic Compounds From Pycnocycla Spinosa Decne. Ex Boiss With Relaxant Effects on Kcl-Induced Contraction in Rat Ileum, Phytochemistry Letters (2014)

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Style	Citing Format
MLA	Zarghi A, et al.. "Synthesis and Calcium Antagonist Activity of 1,4-Dihydropyridines Containing Phenylaminoimidazolyl Substituents." Farmaco, vol. 58, no. 11, 2003, pp. 1077-1081.
APA	Zarghi A, Sadeghi H, Fassihi A, Faizi M, Shafiee A (2003). Synthesis and Calcium Antagonist Activity of 1,4-Dihydropyridines Containing Phenylaminoimidazolyl Substituents. Farmaco, 58(11), 1077-1081.
Chicago	Zarghi A, Sadeghi H, Fassihi A, Faizi M, Shafiee A. "Synthesis and Calcium Antagonist Activity of 1,4-Dihydropyridines Containing Phenylaminoimidazolyl Substituents." Farmaco 58, no. 11 (2003): 1077-1081.
Harvard	Zarghi A et al. (2003) 'Synthesis and Calcium Antagonist Activity of 1,4-Dihydropyridines Containing Phenylaminoimidazolyl Substituents', Farmaco, 58(11), pp. 1077-1081.
Vancouver	Zarghi A, Sadeghi H, Fassihi A, Faizi M, Shafiee A. Synthesis and Calcium Antagonist Activity of 1,4-Dihydropyridines Containing Phenylaminoimidazolyl Substituents. Farmaco. 2003;58(11):1077-1081.
BibTex	@article{ author = {Zarghi A and Sadeghi H and Fassihi A and Faizi M and Shafiee A}, title = {Synthesis and Calcium Antagonist Activity of 1,4-Dihydropyridines Containing Phenylaminoimidazolyl Substituents}, journal = {Farmaco}, volume = {58}, number = {11}, pages = {1077-1081}, year = {2003} }
RIS	TY - JOUR AU - Zarghi A AU - Sadeghi H AU - Fassihi A AU - Faizi M AU - Shafiee A TI - Synthesis and Calcium Antagonist Activity of 1,4-Dihydropyridines Containing Phenylaminoimidazolyl Substituents JO - Farmaco VL - 58 IS - 11 SP - 1077 EP - 1081 PY - 2003 ER -

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