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Investigating Sevoflurane, Remifentanil, and Propofol Effects on Recovery of Patients With Movement Disorders Under General Anesthesia Publisher



Kaviani N1 ; Taghizadeh E2 ; Feyzi G3 ; Moradi F4
Authors
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Authors Affiliations
  1. 1. Department of Oral and Maxillofacial, Dental Research Institute, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Depatment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahed University, Tehran, Iran
  3. 3. Dental Research Center, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Advanced Pharmacy Education and Research Published:2024


Abstract

The present randomized double-blind clinical trial compared the effects of two drug regimens of sevoflurane and remifentanil plus propofol on recovery conditions in adult patients with movement disorders for dental treatments under general anesthesia. Thirty patients were selected among the adult patients who had movement disorders and underwent general anesthesia in the operating room to perform dental procedures. Then, each patient was allocated to one of the control or case groups using a table of random numbers. Anesthesia was induced similarly in both groups using 5 mg/kg sodium thiopental, 1 µg/kg fentanyl, and 0.8 µg/kg atracurium. Then, the first group received sevoflurane with MAC: 1.85 and the Second one received remifentanil plus propofol (propofol 3mg/kg/min and then remifentanil 1µg/kg/min) to maintain anesthesia. The mean score of delirium in recovery was analyzed using the Cox regression test. After the patient entered recovery, the delirium level was evaluated at 5, 10, 15, 30, and 60 minutes using the Nu-DESC checklist. The results revealed that there was no significant difference between the two groups regarding the variables of age, gender, underlying disease, the drugs used by the patient, level of physical ability, the severity of movement disorder, the total number of dental procedures, recovery time, anesthesia time, and mental problems (P value=0.260) and also delirium rate was similar in both. © 2024 Journal of Advanced Pharmacy Education & Research | Published by MERAL Publication
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