Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Three Different Doses of Sufentanil on Changes in Blood Pressure and Heart Rate After Laryngoscopy and Intubation, and Comparison With the Control Group Publisher



Yaraghi A1 ; Honarmand A1 ; Iravani Z2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2017


Abstract

Background: Hemodynamic disorders is a common and serious complication during endotracheal intubation with various suggested preventive methods; but there is no consensus. The aim of this study was to determine the effect of three different doses of sufentanil on heart rate and blood pressure changes after laryngoscopy and endotracheal intubation, and to compare it with the control group. Methods: In a double-blind clinical trial study, 128 patients undergoing surgery with general anesthesia were randomly divided into 4 groups of 32. In the first group, as the control group, the drug was not injected, and the other three groups received 0.1, 0.2, and 0.3 μg/kg sufentanil, respectively, which was injected before laryngoscopy. Hemodynamic parameters were determined at 0, 1, 3, 5, and 10 minutes after laryngoscopy, and were compared between the four groups. Findings: The trend of blood pressure changes during laryngoscopy was significantly different between the four groups; but the changes in heart rate and oxygen saturation were not different between the groups. Changes in the level of hemodynamic parameters showed that the group receiving 0.3 μg/kg sufentanil had higher stability during the laryngoscopy. Conclusion: Dosage of 0.3 μg/kg sufentanil appears to be associated with favorable hemodynamic stability of patients during laryngoscopy and endotracheal tube insertion. © 2017 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Attenuation of Cardiovascular Responses to Laryngoscopy and Tracheal Intubation-Intravenous Sufentanil Vs Pethidine, Middle East Journal of Anesthesiology (2008)
2. A Comparison of Different Doses of Remifentanil and Tracheal Lidocaine on Attenuation of Cardiovascular Responses to Laryngoscopy and Tracheal Intubation, Turkish Journal of Medical Sciences (2009)
3. Comparing the Effect of Dexmedetomidine and Remifentanil on Hemodynamic Indices in Children Undergoing Endotracheal Intubation: A Randomized Clinical Trial, Journal of Mazandaran University of Medical Sciences (2019)
4. Effect of Sufentanil Plus Propofol Versus Fentanyl Plus Propofol on the Cardiovascular Response to Laryngoscopy and Endotracheal Intubation; [تأثیر فنتانیل و سوفنتانیل در ترکیب با پروپوفول بر تغییرات ضربان قلب و فشارخون بعد از لارنگوسکوپی و لولهگذاری تراشه], Journal of Isfahan Medical School (2025)
5. The Comparability of Second Dose Thiopental With Lidocaine in the Attenuation of Cardiovascular Response to Endotracheal Intubation, Iranian Cardiovascular Research Journal (2009)
6. The Effect of Labetalol or Remifentanil on Blood Pressure and Heart Rate After Laryngoscopy and Intubation, Journal of Isfahan Medical School (2017)
7. Tracheal Intubation Without Muscle Relaxants: A Randomized Study of Remifentanil or Alfentanil in Combination With Thiopental, Annals of Saudi Medicine (2008)
8. Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Undergoing Tracheal Intubation for General Anesthesia, Journal of Research in Medical Sciences (2011)
Experts (# of related papers)
View all Related Experts
Azim Honarmand (50)
Mohammad Reza Safavi (45)
Other Related Docs
9. The Effect of Remifentanil on Hemodynamic Response to Laryngeal Mask Airway Insertion in Induction of Anesthesia With Propofol Fentanyl or Propofol Ketamine in Cataract Surgery, Medical Journal of Tabriz University of Medical Sciences (2022)
10. Comparing the Effect of Induction With Propofol, Thiopental Sodium and Etomidate on Hemodynamic Changes and Surgeon Satisfaction During Suspension Laryngoscopy, Journal of Isfahan Medical School (2015)
11. Assessing the Effects of Dexmedetomidine and Labetalol on Changes in Heart Rate and Blood Pressure After Laryngoscopy Compared to a Control Group, Journal of Cellular and Molecular Anesthesia (2020)
12. A Dose-Response Study of Magnesium Sulfate in Suppressing Cardiovascular Responses to Laryngoscopy and Endotracheal Intubation, Journal of Research in Medical Sciences (2005)
13. Evaluating the Effect of Various Doses of Magnesium Sulfate on Cardiovascular Changing and Stimulating Due to Laryngoscopes and Intubation, Journal of Isfahan Medical School (2015)
14. Effect of Low-Dose Ketamine Versus Lidocaine on Hemodynamic Response to Endotracheal Intubation in General Anesthesia: A Prospective, Triple-Blinded, Randomized Controlled Trial, Tehran University Medical Journal (2023)
15. Attenuation of the Pressor Response to Direct Laryngoscopy and Tracheal Intubation: Oral Clonidine Vs. Oral Gabapentin Premedication, Journal of Research in Medical Sciences (2011)
16. Prevention of Propofol-Induced Injection Pain by Sufentanil: A Placebo-Controlled Comparison With Remifentanil, Clinical Drug Investigation (2008)
17. The Comparison of the Effect of Ketamine-Sufentanil Combination and Propofol-Remifentanil Combination on the Quality of Sedation During Painful Procedures in Children With Hematological Malignancies, Journal of Isfahan Medical School (2018)
18. The Role of Magnesium Sulfate in Tracheal Intubation Without Muscle Relaxation in Patients Undergoing Ophthalmic Surgery, Journal of Research in Medical Sciences (2016)
19. Comparing “Acromio-Axillo-Suprasternal Notch Index (Aasi)” As a New Screening Test for Predicting Difficult Laryngoscopy With Four Commonly Used Tests, Journal of Isfahan Medical School (2016)
20. A Comparison of Intraocular Pressure and Hemodynamic Responses to Insertion of Laryngeal Mask Airway or Endotracheal Tube Using Anesthesia With Propofol and Remifentanil in Cataract Surgery, Journal of Research in Medical Sciences (2012)
21. Evaluation of Prophylactic Injection of Two Doses of Tramadol on Heart Rate and Blood Pressure Changes Compared With Control Group After Laryngoscopy and Intubation, Journal of Isfahan Medical School (2016)
22. Comparison of the Premedication Effect of Propofol and Dexamethasone on Reducing Fentanyl-Induced Cough, Journal of Isfahan Medical School (2018)
23. Comparing the Effect of Remifentanil, Propofol and Remifentanil Plus Propofol on the Sedation Score Among Patients Under Phacoemulsification Cataract Surgery, Journal of Isfahan Medical School (2016)
24. Remifentanil-Ketamine Versus Fentanyl-Ketamine Sedation in Patients Undergoing Phacoemulsification With Topical Anesthesia: Comparison of Intraocular Pressure Changes and Sedation Quality, Journal of Research in Medical Sciences (2008)
25. Effect of Controlled Hyperventilation on the Pressor Response to Laryngoscopy and Tracheal Intubation, Middle East Journal of Anesthesiology (2003)
26. Comparing Alfentanil, Sufentanil, Ketamine and Pethidine for Prevention of Postanesthetic Shivering: A Randomized Placebo-Controlled Clinical Trial, Journal of Isfahan Medical School (2015)
27. Comparison of the Effect of Lidocaine and Ketamine on Prevention of Fentanyl-Induced Cough During the Induction of Anesthesia in Children Under General Anesthesia, Journal of Isfahan Medical School (2019)
28. A Comparative Study of the Effect of Anesthesia Induction With the Use of Four Drug Combinations Including 'Propofol,' 'Etomidate-Propofol,' 'Thiopental,' and 'Midazolam-Thiopental' on Hemodynamic Changes During the Insertion of Laryngeal Mask in Eye Surgery, Advanced Biomedical Research (2022)
29. Effect of Etomidate Versus Midazolam-Sodium Thiopental on Attenuating the Cardiovascular Response to Laryngoscopy and Tracheal Intubation, Anesthesiology and Pain Medicine (2024)
30. Investigating Sevoflurane, Remifentanil, and Propofol Effects on Recovery of Patients With Movement Disorders Under General Anesthesia, Journal of Advanced Pharmacy Education and Research (2024)
31. The Effect of Intranasal Administration of Remifentanil at Different Doses on Electroconvulsive Therapy-Induced Hemodynamic Changes in Adults, Journal of Kerman University of Medical Sciences (2025)
32. Comparison of the Effect of Two Doses of Remifentanil Infusion on the Amount of Bleeding, Intraoperative Hemodynamic Changes and Complications After Rhinoplasty Surgery With General Anesthesia; [مقایسه تاثير انفوزیون دو دوز رميفنتانيل بر ميزان خونریزی، تغييرات همودیناميک حين عمل و عوارض پساز عمل جراحی رینوپلاستی پساز بيهوشی عمومی], Tehran University Medical Journal (2023)
33. Comparison of the Effect of Thiopental Sodium-Midazolam Combination on the Hemodynamic Response Between Tracheal Intubation and Laryngeal Mask Airway Insertion: A Clinical Trial Study, Scientific Journal of Kurdistan University of Medical Sciences (2019)
34. The Effect of Using Topical Lidocaine on Blade and Cuff of Laryngoscope, and Tracheal Mucosa on Changes of Heart Rate and Blood Pressure During Laryngoscopy and Intubation, Journal of Isfahan Medical School (2017)
35. Comparing the Effects of Low Doses of Propofol, Ketamine and Combination of Propofol-Ketamine in Prevention of Post-Extubation Coughing and Laryngospasm, Journal of Isfahan Medical School (2014)
36. Comparative Evaluation of Bispectral Index System After Sedation With Midazolam and Propofol Combined With Remifentanil Versus Ketamine in Uncooperative During Dental Procedures, Dental Research Journal (2016)
37. The Comparison of the Effects of Fentanyl and Dexmedetomidine on Hemodynamic Stability in Patients Undergoing Stereotactic Surgery, Journal of Isfahan Medical School (2022)
38. Removal of Laryngeal Mask Airway: Awake or Deep Anesthesia?, Journal of Research in Medical Sciences (2005)
39. Ketamine/Propofol Versus Midazolam/Fentanyl for Procedural Sedation and Analgesia in the Emergency Department: A Randomized, Prospective, Double-Blind Trial, Academic Emergency Medicine (2011)
40. Evaluating the Effect of Adding Furosemide to Hypertonic Saline 5% on the Intracranial Pressure in Candidates of Craniotomy for Resection of Supratentorial Brain Tumors, Journal of Isfahan Medical School (2018)
41. Comparative Study of the Effect of Two Different Doses of Intravenous Labetalol on the Cardiovascular Response to Endotracheal Extubation, Journal of Cardiovascular and Thoracic Research (2023)
42. Comparison of Dexmedetomidine Versus Midazolam on Hemodynamic Parameters, Bleeding, Satisfaction of Surgeons and Patients Who Underwent Laminectomy Surgery by Spinal Anesthesia, Tehran University Medical Journal (2021)
43. Oral Clonidine Premedication Decreases Intraoperative Bleeding in Patients Undergoing Endoscopic Sinus Surgery, Journal of Research in Medical Sciences (2005)
44. Comparison of Low-Dose Naloxone With Ondansetron for Prevention of Sufentanil-Postoperative/Postdischarge Nausea and Vomiting, Archives of Anesthesiology and Critical Care (2024)
45. Comparison the Effects of Etomidate Infusion Versus Ketamine-Midazolam-Fentanyl Combination in Sedation for Cataract Surgery, Journal of Isfahan Medical School (2013)
46. Effects of the Two Doses of Dexmedetomidine on Sedation, Agitation, and Bleeding During Pediatric Adenotonsillectomy, Anesthesiology and Pain Medicine (2021)
47. Comparison of the Effect of Adding Ketamine to Sodium Thiopental and Propofol on the Quality of Sedation in Cataract Surgery With Phacoemulsification Under Local Anesthesia and Intravenous Sedation; [مقایسه‌ی اثر افزودن کتامین به سدیم تیوپنتال و پروپوفول بر کیفیت آرام‌بخشی در جراحی آب مروارید با فیکوامولسیفیکاسیون تحت بی‌حسی موضعی و آرام‌بخشی داخل وریدی], Journal of Isfahan Medical School (2024)
48. Comparing the Effects of Magnesium Sulfate and Nitroglycerin on the Control of Hypertension During and After Cataract Surgery Under Local Anesthesia and Intravenous Sedation, Journal of Isfahan Medical School (2016)
49. The Effects of Intravenous Fluids Temperature on Perioperative Hemodynamic Situation, Post-Operative Shivering, and Recovery in Orthopaedic Surgery., Canadian operating room nursing journal (2007)
50. Comparative Evaluation of the Effects of Different Doses of Labetalol on Cardiovascular Response to Tracheal Intubation, Journal of Isfahan Medical School (2016)