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Circular Rnas-Mediated Angiogenesis in Human Cancers Publisher Pubmed



Ghaedrahmati F1 ; Nasrolahi A2 ; Najafi S3 ; Mighani M4 ; Anbiyaee O5 ; Haybar H6 ; Assareh AR6 ; Kempisty B7, 8, 9 ; Dziegiel P10 ; Azizidoost S6 ; Farzaneh M11
Authors

Source: Clinical and Translational Oncology Published:2023


Abstract

Circular RNAs (circRNAs) as small non-coding RNAs with cell, tissue, or organ-specific expression accomplish a broad array of functions in physiological and pathological processes such as cancer development. Angiogenesis, a complicated multistep process driving a formation of new blood vessels, speeds up tumor progression by supplying nutrients as well as energy. Abnormal expression of circRNAs reported to affect tumor development through impressing angiogenesis. Such impacts are introduced as constant with different tumorigenic features known as “hallmarks of cancer”. In addition, deregulated circRNAs show possibilities to prognosis and diagnosis both in the prophecy of prognosis in malignancies and also their prejudice from healthy individuals. In the present review article, we have evaluated the angiogenic impacts and anti-angiogenic managements of circRNAs in human cancers. © 2023, The Author(s), under exclusive licence to Federacion de Sociedades Espanolas de Oncologia (FESEO).
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