Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Landscape of Circrnas in Gliomas Temozolomide Resistance: Insights Into Molecular Pathways Publisher



Mafi A1, 2 ; Hedayati N3 ; Kahkesh S4 ; Khoshayand S5 ; Alimohammadi M6 ; Farahani N7 ; Hushmandi K8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. School of Medicine, Iran University of Medical Science, Tehran, Iran
  4. 4. Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  5. 5. School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Source: Non-coding RNA Research Published:2024


Abstract

As the deadliest type of primary brain tumor, gliomas represent a significant worldwide health concern. Circular RNA (circRNA), a unique non-coding RNA molecule, seems to be one of the most alluring target molecules involved in the pathophysiology of many kinds of cancers. CircRNAs have been identified as prospective targets and biomarkers for the diagnosis and treatment of numerous disorders, particularly malignancies. Recent research has established a clinical link between temozolomide (TMZ) resistance and certain circRNA dysregulations in glioma tumors. CircRNAs may play a therapeutic role in controlling or overcoming TMZ resistance in gliomas and may provide guidance for a novel kind of individualized glioma therapy. To address the biological characteristics of circRNAs and their potential to induce resistance to TMZ, this review has highlighted and summarized the possible roles that circRNAs may play in molecular pathways of drug resistance, including the Ras/Raf/ERK PI3K/Akt signaling pathway and metabolic processes in gliomas. © 2024 The Authors
Related Docs
View other Related Docs
1. Mechanistic Insights Into Circrna-Mediated Regulation of Pi3k Signaling Pathway in Glioma Progression, Pathology Research and Practice (2024)
2. The Importance of the Circrna/Wnt Axis in Gliomas: Biological Functions and Clinical Opportunities, Pathology Research and Practice (2024)
3. Circular Rnas and Glioblastoma Multiforme: Focus on Molecular Mechanisms, Cell Communication and Signaling (2022)
4. The Emerging Role of Circular Rnas in Cisplatin Resistance in Ovarian Cancer: From Molecular Mechanism to Future Potential, Non-coding RNA Research (2024)
5. The Function and Mechanism of Circrnas in 5-Fluorouracil Resistance in Tumors: Biological Mechanisms and Future Potential, Pathology Research and Practice (2024)
6. Circular Rnas and Cervical Cancer: Friends or Foes? a Landscape on Circrna-Mediated Regulation of Key Signaling Pathways Involved in the Onset and Progression of Hpv-Related Cervical Neoplasms, Cell Communication and Signaling (2024)
7. The Potential Role of Circular Rnas -Regulated Pi3k Signaling in Non-Small Cell Lung Cancer: Molecular Insights and Clinical Perspective, Pathology Research and Practice (2024)
8. Novel Insights Into the Role of Circular Rnas in Parkinson Disease: An Emerging Renaissance in the Management of Neurodegenerative Diseases, Journal of Neuroscience Research (2022)
Experts (# of related papers)
View all Related Experts
Behrooz Ghezelbash (4)
Maryam Derakhshan (3)
Other Related Docs
9. Circular Rnas in Alzheimer’S Disease: A New Perspective of Diagnostic and Therapeutic Targets, CNS and Neurological Disorders - Drug Targets (2023)
10. Non-Coding Rnas and Glioblastoma: Insight Into Their Roles in Metastasis, Molecular Therapy Oncolytics (2022)
11. Exosomal Noncoding Rnas: Key Players in Glioblastoma Drug Resistance, Molecular and Cellular Biochemistry (2021)
12. Non-Coding Rnas and Brain Tumors: Insights Into Their Roles in Apoptosis, Frontiers in Cell and Developmental Biology (2022)
13. Non-Coding Rnas in Leukemia Drug Resistance: New Perspectives on Molecular Mechanisms and Signaling Pathways, Annals of Hematology (2024)
14. The Landscape of Exosomal Non-Coding Rnas in Breast Cancer Drug Resistance, Focusing on Underlying Molecular Mechanisms, Frontiers in Pharmacology (2023)
15. Circular Rnas: New Players in Thyroid Cancer, Pathology Research and Practice (2020)
16. Recent Insights Into the Roles of Circular Rnas in Human Brain Development and Neurologic Diseases, International Journal of Biological Macromolecules (2023)
17. The Role of Curcumin in Modulating Circular Rnas and Long Non-Coding Rnas in Cancer, Clinical and Translational Oncology (2024)
18. Circular Rnas; Powerful Microrna Sponges to Overcome Diabetic Nephropathy, Pathology Research and Practice (2021)
19. Circular Rnas: Pivotal Role in the Leukemogenesis and Novel Indicators for the Diagnosis and Prognosis of Acute Myeloid Leukemia, Frontiers in Oncology (2023)
20. Circular Rnas: Epigenetic Regulators in Cancerous and Noncancerous Skin Diseases, Cancer Gene Therapy (2020)
21. Recent Insights Into the Microrna-Dependent Modulation of Gliomas From Pathogenesis to Diagnosis and Treatment, Cellular and Molecular Biology Letters (2022)
22. A Spotlight on the Interplay Between Wnt/Β-Catenin Signaling and Circular Rnas in Hepatocellular Carcinoma Progression, Frontiers in Oncology (2023)
23. Circular Rnas: Emerging Modulators in the Pathophysiology of Polycystic Ovary Syndrome and Their Clinical Implications, Current Molecular Medicine (2024)
24. Circular Rnas: New Genetic Tools in Melanoma, Biomarkers in Medicine (2020)
25. The Regulatory Role of Circular Rnas As Mirna Sponges in Cervical Cancer, Current Signal Transduction Therapy (2023)
26. Circular Rnas: A Small Piece in the Heart Failure Puzzle, Functional and Integrative Genomics (2024)
27. Down-Regulation of Circular Rna Itch and Circhipk3 in Gastric Cancer Tissues, Turkish Journal of Medical Sciences (2019)
28. Circrnas As a Novel Class of Potential Diagnostic Biomarkers in Bipolar Disorders, Current Medicinal Chemistry (2024)
29. Glioblastoma Multiforme: Insights Into Pathogenesis, Key Signaling Pathways, and Therapeutic Strategies, Molecular Cancer (2025)
30. Circular Rnas-Mediated Angiogenesis in Human Cancers, Clinical and Translational Oncology (2023)
31. Pi3k/Akt/Mtor Signaling Pathway Modulation by Circular Rnas in Breast Cancer Progression, Pathology Research and Practice (2023)
32. Melatonin Targeting Non-Coding Rnas in Cancer: Focus on Mechanisms and Potential Therapeutic Targets, European Journal of Pharmacology (2023)
33. Microrna Dysregulation and Its Impact on Apoptosis-Related Signaling Pathways in Myelodysplastic Syndrome, Pathology Research and Practice (2024)
34. Signaling Pathways Governing Glioma Cancer Stem Cells Behavior, Cellular Signalling (2023)
35. Electrochemical Biosensors for Early Diagnosis of Glioblastoma, Clinica Chimica Acta (2024)
36. Resveratrol As an Antitumor Agent for Glioblastoma Multiforme: Targeting Resistance and Promoting Apoptotic Cell Deaths, Acta Histochemica (2023)
37. Gastrointestinal Cancer Drug Resistance: The Role of Exosomal Mirnas, Molecular Biology Reports (2022)
38. The Significant Role of Micrornas in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application, Cellular and Molecular Neurobiology (2023)
39. Microrna: A Novel Target of Curcumin in Cancer Therapy, Journal of Cellular Physiology (2018)
40. System Biology Analysis to Develop Diagnostic Biomarkers, Monitoring Pathological Indexes, and Novel Therapeutic Approaches for Immune Targeting Based on Maggot Bioactive Compounds and Polyphenolic Cocktails in Mice With Gastric Cancer, Environmental Research (2023)
41. Non-Coding Rnas and Neurodegenerative Diseases: Information of Their Roles in Apoptosis, Molecular Neurobiology (2024)
42. A Review on Expression and Regulatory Mechanisms of Mir-337-3P in Cancer, Journal of Biomolecular Structure and Dynamics (2024)
43. Glioblastoma: Exosome and Microrna As Novel Diagnosis Biomarkers, Cancer Gene Therapy (2016)
44. Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression, EXCLI Journal (2023)
45. Exosomal Micrornas and Long Noncoding Rnas: Novel Mediators of Drug Resistance in Lung Cancer, Journal of Cellular Physiology (2022)
46. Integrative Computational In-Depth Analysis of Dysregulated Mirna-Mrna Interactions in Drug-Resistant Pediatric Acute Lymphoblastic Leukemia Cells: An Attempt to Obtain New Potential Gene-Mirna Pathways Involved in Response to Treatment, Tumor Biology (2016)
47. Resveratrol Inhibits Glioblastoma Cells and Chemoresistance Progression Through Blockade P-Glycoprotein and Targeting Akt/Pten Signaling Pathway, Chemico-Biological Interactions (2023)
48. Targeting Glioma Cells With Nutraceuticals: Therapeutic Effects Based on Molecular Mechanisms, New Evidence and Perspectives, Mini-Reviews in Medicinal Chemistry (2023)
49. Mir-1236: Key Controller of Tumor Development and Progression: Focus on the Biological Functions and Molecular Mechanisms, Pathology Research and Practice (2023)
50. Exploring Potential Roles of Long Non-Coding Rnas in Cancer Immunotherapy: A Comprehensive Review, Frontiers in Immunology (2024)