New Treatment Protocol for Primary Nocturnal Enuresis in Children According to Ultrasound Bladder Measurements Pubmed



Azhir A¹ ; Gheissari A¹ ; Fragzadegan Z² ; Adebi A¹ Show Affiliations
Source: Saudi Medical Journal Published:2008

Abstract

Objective: To evaluate the response rate of various modalities of therapy in primary nocturnal enuretic children according to the ultrasound bladder volume and wall thickness index (BVWI) measurements. Methods: From February 2006 to November 2007, a total of 31 children, aged 6-12 years old were enrolled in a clinical trial at the Faculty of Medicine, Isfahan Medical University, Isfahan, Iran. Based on BVWI they were divided into 3 groups as follows: Group 1 (BVWI < 70%) was treated with oral desmopressin. and oxybutynin; Group 2 (BVWI70%to<130%) was treated with oral desmopressin. Group 3 (BVWI>130%) was treated with oral desmopressin accompanied by double-voiding technique and scheduled voiding. All of them were treated for 3 months. Results: Significant reductions in mean bed-wetting frequency before and after first treatment cycle were observed in all groups (p<0.05). The complete respone rate was 70% in Group 1, 25% in Group 2, and 20% in Group 3. Overall, the complete and partial response rate was 9/10 (90%) children in Group 1, 13/16 (81%) in Group 2, and 3/5 (60%) in Group 3. Bedwetting frequency significantly decreased at the first and second treatment cycles in Group 2 (p