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Increased Insulin Sensitivity by Metformin Enhances Intense-Pulsed-Light- Assisted Hair Removal in Patients With Polycystic Ovary Syndrome Publisher Pubmed



Rezvanian H1 ; Adibi N2 ; Siavash M1, 4 ; Kachuei A1 ; Shojaeemoradie F3 ; Asilian A2
Authors
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Authors Affiliations
  1. 1. Isfahan Endocrine and Metabolism Research Center, Isfahan, Iran
  2. 2. Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Wolfson Centre for Translational Research, Diabetes and Endocrinology, Postgraduate Medical School, University of Surrey, Guildford, United Kingdom
  4. 4. Isfahan University of Medical Sciences, Isfahan Endocrine and Metabolism Research Center, Sedigheh Tahereh Medical Research Complex, Isfahan 8187698191, Khorram Street, Iran

Source: Dermatology Published:2009


Abstract

Background: Polycystic ovary syndrome (PCOS) is an insulin-resistant state with hirsutism as a common manifestation. Objective: We hypothesized that treatment with metformin would improve the cosmetic effects of intense pulsed light (IPL) therapy for hair removal in PCOS patients. Methods: In a prospective randomized controlled trial, 70 PCOS patients randomly received metformin (1,500 mg daily) + IPL therapy or IPL therapy alone for 5 IPL sessions during a 6-month period, followed by an additional 6 months of observation. Hirsutism score, homeostasis model assessment for insulin resistance (HOMA-IR), free androgen index (FAI) and patient satisfaction were evaluated at every visit. Results: Fifty-two patients finished the study. Hirsutism was significantly better controlled in the metformin group (p = 0.009). Patient satisfaction was significantly better in the metformin group at the end of the observation period (52.9 vs. 34.1%, p = 0.019). HOMA-IR and FAI scores improved after metformin + IPL treatment (p < 0.05). Conclusion: Adding metformin to IPL in women with PCOS results in a significant improvement in insulin sensitivity and hirsutism. Copyright © 2008 S. Karger AG.
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