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Therapeutic Effects of Mesenchymal Stem Cells-Derived Extracellular Vesicles’ Mirnas on Retinal Regeneration: A Review Publisher Pubmed

Summary: A study found tiny cell particles may help treat blindness from retinal diseases using stem cell compounds. Could this lead to new eye treatments? #StemCellResearch #EyeHealth

Rajool Dezfuly A1 ; Safaee A1 ; Salehi H1
Authors

Source: Stem Cell Research and Therapy Published:2021


Abstract

Extracellular vesicles (EVs), which consist of microvesicles and exosomes, are secreted from all cells to transform vital information in the form of lipids, proteins, mRNAs and small RNAs such as microRNAs (miRNAs). Many studies demonstrated that EVs’ miRNAs have effects on target cells. Numerous people suffer from the blindness caused by retinal degenerations. The death of retinal neurons is irreversible and creates permanent damage to the retina. In the absence of acceptable cures for retinal degenerative diseases, stem cells and their paracrine agents including EVs have become a promising therapeutic approach. Several studies showed that the therapeutic effects of stem cells are due to the miRNAs of their EVs. Considering the effects of microRNAs in retinal cells development and function and studies which provide the possible roles of mesenchymal stem cells-derived EVs miRNA content on retinal diseases, we focused on the similarities between these two groups of miRNAs that could be helpful for promoting new therapeutic techniques for retinal degenerative diseases. © 2021, The Author(s).
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