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Viral Pathophysiology of Multiple Sclerosis: A Role for Epstein-Barr Virus Infection? Publisher



Maghzi AH1, 2, 3 ; Marta M1 ; Bosca I1, 4 ; Etemadifar M2, 3 ; Dobson R1 ; Maggiore C1 ; Giovannoni G1 ; Meier UC1
Authors
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Authors Affiliations
  1. 1. Neuroimmunology Unit, Centre for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
  2. 2. Isfahan Research Committee of Multiple Sclerosis (IRCOMS), Isfahan, Iran
  3. 3. Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Neurology Department, La Fe University Hospital, Valencia, Spain

Source: Pathophysiology Published:2011


Abstract

Multiple sclerosis (MS) is the most common inflammatory demyelinating and degenerative disease of the CNS. The cause of MS is unknown but environmental risk factors are implicated in MS. Several viruses have been proposed as a trigger for MS, and lately Epstein-Barr virus (EBV) has become the leading candidate. An infectious aetiology fits with a number of epidemiological observations in addition to the immunopathological features of the disease. In this review we will summarize the emerging evidence, which demonstrates a strong association between EBV infection and MS. The conundrum remains as to whether EBV is directly involved in the pathophysiology of MS, or alternatively if the immunopathology of MS somehow affects the regulation of EBV infection. © 2010 Elsevier Ireland Ltd.
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