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Cytomegalovirus and Varicella Zoster Virus Seropositivity of Iranian Patients With Multiple Sclerosis: A Population-Based Study Publisher Pubmed



Karampoor S1 ; Zahednasab H2 ; Ramagopalan S3 ; Mehrpour M4 ; Etemadifar M5 ; Alsahebfosoul F6 ; Keyvani H1
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
  3. 3. Evidera, London, United Kingdom
  4. 4. Department of Neurology, Firoozgar Hospital, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences (IUMS), Tehran, Iran
  5. 5. Neurology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Iran
  6. 6. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Iran

Source: Journal of Neuroimmunology Published:2017


Abstract

Multiple Sclerosis is a demyelinating disease of the central nervous system (CNS) affecting young individuals with age range of 20–40 years of age. The precise mechanism underlying the disease is still unclear. Some viruses have been proposed to play roles in disease causation. In this study, we recruited 800 MS patients along with 1000 healthy individuals to determine the seropositivity of anti-CMV and anti-VZV IgG titers using enzyme-linked immunosorbent assay (ELISA). Our results showed significant higher titers of anti-CMV and anti-VZV IgG titers in serum of MS patients with respect to healthy individuals (for both p < 0.001). It seems that CMV and VZV play a key role in MS pathogenesis. © 2017
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