Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Relationship Between Body Mass Index, Risk of Venous Thromboembolism and Pulmonary Embolism: A Systematic Review and Dose-Response Meta-Analysis of Cohort Studies Among Four Million Participants Publisher Pubmed



Rahmani J1 ; Haghighian Roudsari A2 ; Bawadi H3 ; Thompson J4 ; Khalooei Fard R5 ; Clark C6 ; Ryan PM7 ; Ajami M2 ; Rahimi Sakak F5 ; Salehisahlabadi A5 ; Abdulazeem HM8 ; Jamali MR9 ; Mirzay Razaz J2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, Student Research Committee, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Food and Nutrition Policy and Planning, National Nutrition and Food Technology Research Institute, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Science, Tehran, Iran
  3. 3. College of Health Sciences, QU-Health, Qatar University, Doha, Qatar
  4. 4. Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, United Kingdom
  5. 5. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, United Kingdom
  7. 7. School of Medicine, University College Cork, Cork, Ireland
  8. 8. Arab Diploma in Family Medicine, AICPD, Egypt
  9. 9. Students' Research Committee, Department of Clinical Nutrition School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Thrombosis Research Published:2020


Abstract

Background: The relationship between body mass index (BMI) and risk of venous thromboembolism (VTE) and pulmonary embolism (PE) is a controversial issue. This dose-response meta-analysis was performed to investigate the association between BMI and risk of VTE and PE incidence based on cohort studies. Method: A comprehensive systematic search was conducted up to August 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane. DerSimonian and Laird random-effects models were run to estimate combined hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out based on BMI values. Results: Eleven articles with 16 arms and 3,910,747 participants were eligible for inclusion in this systematic review and meta-analysis. Pooled results showed a positive association between BMI and risk of VTE in the obese participants compared to participants classified in the normal BMI category (HR: 1.62, 95% CI: 1.29–2.04, I2 = 95%). Furthermore, results showed a significant association between lower BMI (underweight versus normal BMI category) and reduced risk of PE (HR: 0.80, 95% CI: 0.70–0.92, I2 = 9%) and higher risk of PE in obese versus normal BMI participants (HR: 2.24, 95% CI: 1.93–2.60, I2 = 0%). There was a significant linear relationship between BMI and risk of VTE (p < 0.001) and PE (p < 0.001). Conclusions: This systematic review and dose-response meta-analysis with 3,910,747 participants highlights obesity as a significant risk factor related to the incidence of VTE and PE. © 2020 Elsevier Ltd
Related Docs
View other Related Docs
1. Multiple Sclerosis and the Incidence of Venous Thromboembolism: A Systematic Review and Meta-Analysis, Journal of Thrombosis and Thrombolysis (2023)
2. Comparison of Pulmonary Emboli Management Between Pulmonary Emboli Response Team and the Conventional Method: The First Study From Iran, Critical Pathways in Cardiology (2022)
3. The Metabolic Syndrome and the Risk of Cerebral Venous and Sinus Thrombosis: A Case–Control Study, Neurology Asia (2022)
4. Predictors of Metabolic Syndrome in the Iranian Population: Waist Circumference, Body Mass Index, or Waist to Hip Ratio?, Cholesterol (2013)
5. The Predictive Factors of Recurrent Deep Vein Thrombosis, ARYA Atherosclerosis (2011)
6. A Systematic Review and Meta-Analysis of Prospective Studies on Obesity and Risk of Inflammatory Bowel Disease, Nutrition Reviews (2022)
7. Dietary Intake of Total, Animal and Plant Proteins and the Risk of Coronary Heart Disease and Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
8. Discriminatory Ability of Visceral Adiposity Index As an Indicator for Modeling Cardio-Metabolic Risk Factors in Pediatric Population: The Caspian-V Study, Journal of Cardiovascular and Thoracic Research (2019)
Experts (# of related papers)
View all Related Experts
Masoumeh Sadeghi (6)
Roya Kelishadi (5)
Other Related Docs
9. Triglyceride Glucose-Waist Circumference As a Predictor of Mortality and Subtypes of Cardiovascular Disease: A Systematic Review and Meta-Analysis, Diabetology and Metabolic Syndrome (2025)
10. Validity of Self-Reported Height, Weight, Body Mass Index, and Waist Circumference in Iranian Adults, International Journal of Preventive Medicine (2021)
11. The Effect of Green Coffee Extract Supplementation on Anthropometric Measures in Adults: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Medicine (2020)
12. Anthropometric Indicators of Adiposity Related to Body Weight and Body Shape As Cardiometabolic Risk Predictors in British Young Adults: Superiority of Waist-To-Height Ratio, Journal of Obesity (2018)
13. Adherence to the Healthy Eating Index and Alternative Healthy Eating Index Dietary Patterns and Mortality From All Causes, Cardiovascular Disease and Cancer: A Meta-Analysis of Observational Studies, Journal of Human Nutrition and Dietetics (2017)
14. Does Cocoa/Dark Chocolate Supplementation Have Favorable Effect on Body Weight, Body Mass Index and Waist Circumference? a Systematic Review, Meta-Analysis and Dose-Response of Randomized Clinical Trials, Critical Reviews in Food Science and Nutrition (2019)
15. Association of Adult Height With Cardiovascular Mortality: A Systematic Review and Meta-Analysis of Cohort Studies, International Journal of Clinical Practice (2022)
16. Seeing the Forest for the Trees: How to Interpret a Meta-Analysis Forest Plot, Journal of Advanced Nursing (2021)
17. Final Height in Children and Adolescents With Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis, Hormones (2024)
18. Effect of Sumac Powder Supplementation on Anthropometric Indices: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, Journal of Herbal Medicine (2023)
19. Tri-Ponderal Mass Index and Body Mass Index in Prediction of Pediatric Metabolic Syndrome: The Caspian-V Study, Archives of Endocrinology and Metabolism (2020)
20. Association Between Body Composition Indices and Vascular Health: A Systematic Review and Meta-Analysis, Eating and Weight Disorders (2025)
21. Obesity and Thyroid Cancer: Unraveling the Connection Through a Systematic Review and Meta-Analysis of Cohort Studies, Journal of Diabetes and Metabolic Disorders (2024)
22. Alpha-Lipoic Acid Supplement in Obesity Treatment: A Systematic Review and Meta-Analysis of Clinical Trials, Clinical Nutrition (2018)
23. Assessment of Lytic Therapy Effect in Patients With Intermediate-High Risk Pulmonary Embolism for Prevention of Chronic Thromboembolic Pulmonary Hypertension: A Randomized, Double-Blind Trial, Health Science Reports (2024)
24. The Association Between Fat Mass and the Risk of Breast Cancer: A Systematic Review and Meta-Analysis, Clinical Nutrition (2019)
25. The Association Between Skeletal Muscle Mass Index (Smi) and Survival After Gastrectomy: A Systematic Review and Meta-Analysis of Cohort Studies, European Journal of Surgical Oncology (2023)
26. Investigating the Link Between Coronary Artery Calcification and Atrial Fibrillation: A Systematic Review and Meta-Analysis, Medicine (United States) (2024)
27. Hyponatremia and 30 Days Mortality of Patients With Acute Pulmonary Embolism, Journal of Research in Medical Sciences (2015)
28. Assessing Body Shape Index As a Risk Predictor for Cardiovascular Diseases and Metabolic Syndrome Among Iranian Adults, Nutrition (2014)
29. Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies, Journal of Pharmacy and Pharmaceutical Sciences (2016)
30. The Effect of Magnesium Supplementation on Anthropometric Indices: A Systematic Review and Dose-Response Meta-Analysis of Clinical Trials, British Journal of Nutrition (2021)
31. Dietary Poultry Intake and the Risk of Stroke: A Dose–Response Meta-Analysis of Prospective Cohort Studies, Clinical Nutrition ESPEN (2018)
32. Effects of Sodium-Glucose Co-Transporter-2 Inhibitors on Anthropometric Indices and Metabolic Markers in Overweight/Obese Individuals Without Diabetes: A Systematic Review and Meta-Analysis, Current Medical Research and Opinion (2022)
33. Association of Dietary Inflammatory Potential With Cardiometabolic Risk Factors and Diseases: A Systematic Review and Dose–Response Meta-Analysis of Observational Studies, Diabetology and Metabolic Syndrome (2020)
34. Utility of Waist-To-Height Ratio, Waist Circumference and Body Mass Index in Predicting Clustered Cardiometabolic Risk Factors and Subclinical Vascular Phenotypes in Children and Adolescents: A Pooled Analysis of Individual Data From 14 Countries, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2024)
35. Fruit and Vegetable Intake and Cognitive Impairment: A Systematic Review and Meta-Analysis of Observational Studies, European Journal of Clinical Nutrition (2018)
36. Cholesterol to Saturated Fat Index (Csi), Metabolic Parameters and Inflammatory Factors Among Obese Individuals, BMC Endocrine Disorders (2024)
37. Sleep Duration and Sarcopenia Risk: A Systematic Review and Dose-Response Meta-Analysis, Sleep and Breathing (2020)
38. Association of a Body Shape Index and Hip Index With Cardiometabolic Risk Factors in Children and Adolescents: The Caspian-V Study, Journal of Diabetes and Metabolic Disorders (2021)
39. The Effects of Purslane Consumption on Obesity Indices: A Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Food Biochemistry (2023)
40. Comparison of Outcomes and Complications in Conventional Versus Ultrasound-Accelerated Catheter Directed Thrombolysis for Treatment of Pulmonary Embolism: A Systematic Review and Meta-Analysis, Perfusion (United Kingdom) (2023)
41. Normal Weight Obesity and Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis, Frontiers in Endocrinology (2022)
42. Is Thromboprophylaxis Effective in Reducing the Pulmonary Thromboembolism?, ARYA Atherosclerosis (2012)
43. Social Jetlag and Obesity: A Systematic Review and Meta-Analysis, Obesity Reviews (2024)
44. Elevated Liver Enzymes and Cardiovascular Mortality: A Systematic Review and Dose-Response Meta-Analysis of More Than One Million Participants, European Journal of Gastroenterology and Hepatology (2019)
45. The Association of Neck Circumference With Risk of Metabolic Syndrome and Its Components in Adults: A Systematic Review and Meta-Analysis, Nutrition, Metabolism and Cardiovascular Diseases (2018)
46. The Association of Anthropometric Indices and Cardiac Function in Healthy Adults, ARYA Atherosclerosis (2019)
47. The Effects of Supplementation With L-Arginine on Anthropometric Indices and Body Composition in Overweight or Obese Subjects: A Systematic Review and Meta-Analysis, Journal of Functional Foods (2020)
48. Systematic Review and Meta-Analysis of Diagnosing Gestational Diabetes Mellitus With One-Step or Two-Step Approaches and Associations With Adverse Pregnancy Outcomes, International Journal of Gynecology and Obstetrics (2018)
49. Anthropometric Indicators Associated With Dyspnea and Spirometric Parameters in Patients With Chronic Obstructive Pulmonary Disease, Tanaffos (2016)
50. Possible Anti-Obesity Effects of Phytosterols and Phytostanols Supplementation in Humans: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2019)