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The Effects of Supplementation With Cynara Scolymus L. on Anthropometric Indices: А Systematic Review and Dose-Response Meta-Analysis of Clinical Trials Publisher Pubmed



Hemati N1 ; Venkatakrishnan K2 ; Yarmohammadi S1 ; Moradi M1 ; Moravejolahkami AR3 ; Hadi A4 ; Moradi S5 ; Aneva IY6 ; Farzaei MH7
Authors
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Authors Affiliations
  1. 1. Internal Medicine Department, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. School of Nutrition, Chung Shan Medical University, 110, Sec. 1, Jianguo North Road, Taichung City, Taiwan
  3. 3. Department of Clinical Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Halal Research Center of IRI, FDA, Tehran, Iran
  5. 5. Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria
  7. 7. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Complementary Therapies in Medicine Published:2021


Abstract

Background: Studies on the efficacy of artichoke administration on anthropometric indices gave different outcomes. Hence, a systematic review and dose-response meta-analysis were accomplished to understand the effects of artichoke administration on anthropometric indices. Methods: Related clinical trials were found by searching in PubMed, Embase, the Cochrane Library and Scopus databases up to 29 February 2020. Weighted Mean Differences (WMD) were analyzed using a random-effects model. Heterogeneity, publication bias and sensitivity analysis were assessed for anthropometric indices. Results: Pooled analysis of 10 randomized controlled trials (RCTs) suggested that the artichoke administration has effect on waist circumference (WMD: -1.11 cm, 95 % CI: -2.08 to - 0.14), as opposed to the other anthropometric indices including weight (WMD: -0.62 kg, 95 % CI: -1.86 to 0.61) or BMI (WMD: -0.12, 95 % CI: -0.43 to 0.20). However, the analysis of the subgroups according to the health status showed that artichoke supplementation in hypertensive patients significantly reduced weight (WMD: -2.34 kg, 95 % CI: -3.11 to -1.57) but not the other indicators (WMD: -0.06 kg, 95 % CI: 0.78 to 0.67). Conclusions: The artichoke supplementation has effect on the waist circumference, but not on the other anthropometric indices. For establishment of more accurate conclusion more studies with longer administration duration are need to be done. © 2020 The Author(s)
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