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Comparing the Effects of Pregabalin and Clonidine on Postoperative Pain in Tonsillectomy: A Randomized, Double-Blind, Prospective Clinical Trial Publisher Pubmed



Sane S1 ; Vash RA1 ; Rahmani N2 ; Talebi H3 ; Golabi P4 ; Kalashipour F5 ; Heidari P6 ; Hatami MF6 ; Haki BK1 ; Morwati S7
Authors
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Authors Affiliations
  1. 1. Department of Anesthesiology, Urmia Imam Khomeini Hospital, Urmia University of Medical Science, Urmia, Iran
  2. 2. College of Medical, Veterinary & Life Science, University of Glasgow, Glasgow, United Kingdom
  3. 3. Department of Medicine, Isfahan University of medical sciences, Isfahan, Iran
  4. 4. Department of Anesthesiology, Omid Charity Hospital, Urmia University of Medical Science, Urmia, Iran
  5. 5. Department of Operating Room, Kurdistan University of Medical Sciences, Urmia, Iran
  6. 6. Department of Medicine, Urmia University of Medical Science, Urmia, Iran
  7. 7. Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Reviews on Recent Clinical Trials Published:2022


Abstract

Background: Tonsillectomy is one of the most common surgical procedures. This study compared the effect of Pregabalin and Clonidine on postoperative pain in adult patients undergoing elective tonsillectomy. Methods: This randomized, double-blind, prospective clinical trial was conducted among 92 patients aged 20 to 50. The clonidine group (C) was given 150 μg of clonidine tablet 90 minutes before surgery, and the pregabalin group (P) was given 300 mg of pregabalin tablet 90 minutes before surgery. The results were analyzed by SPSS 25, and statistical analysis consisted of chi-square, T-test, and χ2 tests, and a p-value less than 0.05 was considered significant. Results: The mean pain score and analgesic consumption scores in the pregabalin group were lower than in the clonidine group. According to the t-test, there was a significant difference between the two groups regarding pain score and analgesic consumption (p <0.05). Hemodynamic variation in both groups had no significant differences (p >0.05). Conclusion: The present study showed that pregabalin reduced postoperative pain and analgesic consumption more effectively than clonidine. © 2022 Bentham Science Publishers.
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