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Ac-Mode of Chemotherapy As a Trigger of Cardiac Syndrome X: A Case Study Publisher Pubmed



Avagimyan A1 ; Mkrtchyan L2 ; Abrahomovich O3 ; Sheibani M4 ; Guevorkyan A1 ; Sarrafzadegan N5 ; Kozhukhov S6 ; Agati L7 ; Astengiano R8 ; Zaritska V9 ; Jndoyan Z10
Authors
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Authors Affiliations
  1. 1. Internal Medicine Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  2. 2. Cardiology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  3. 3. Internal Medicine Department, D. Halytsky Lviv National Medical University, Lviv, Ukraine
  4. 4. School of Medicine, Iran University of Medical Sciences, Teheran, Iran
  5. 5. Isfahan Cardiovascular-Research Center, Isfahan University of Medical Science, Isfahan, Iran
  6. 6. Clinical Pharmacology and Cardio-Oncology Department and Cardio-Oncology Center, M.D. Strazhesko Institute of Cardiology, Kiev, Ukraine
  7. 7. Sapienza University of Rome, Rome, Italy
  8. 8. School of Medicine, Insubria University Varese, Lombardy, Italy
  9. 9. Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine
  10. 10. Internal Disease Propedeutics Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia

Source: Current Problems in Cardiology Published:2022


Abstract

In the period of dynamic development of pharmacological possibilities in the modern oncology, unfortunately, the issue of cardiotoxicity of chemotherapy did not lost its urgent value. Cardiotoxicity implies structural and functional myocardial alteration, together with an increase in the concentration of highly sensitive markers of myocardial necrosis, in particular T and I troponins, and N-terminal pro-BNP, as well as with a subclinical or clinical decrease in the LVEF. It is noteworthy that cardiotoxicity is manifested not only by the development of anthracycline cardiomyopathy with a high risk of convention into heart failure. It also can cause various cardiovascular pathologies, in particular cardiac syndrome X. This study described chemotherapy-induced microvascular angina in 23-year-old otherwise heathy woman. The diagnosis is challenging for doctors, since microvascular flow may be only detected by using functional test. © 2021 Elsevier Inc.