Ac-Mode of Chemotherapy As a Trigger of Cardiac Syndrome X: A Case Study Publisher Pubmed



Avagimyan A¹ ; Mkrtchyan L² ; Abrahomovich O³ ; Sheibani M⁴ ; Guevorkyan A¹ ; Sarrafzadegan N⁵ ; Kozhukhov S⁶ ; Agati L⁷ ; Astengiano R⁸ ; Zaritska V⁹ ; Jndoyan Z¹⁰
Source: Current Problems in Cardiology Published:2022

Abstract

In the period of dynamic development of pharmacological possibilities in the modern oncology, unfortunately, the issue of cardiotoxicity of chemotherapy did not lost its urgent value. Cardiotoxicity implies structural and functional myocardial alteration, together with an increase in the concentration of highly sensitive markers of myocardial necrosis, in particular T and I troponins, and N-terminal pro-BNP, as well as with a subclinical or clinical decrease in the LVEF. It is noteworthy that cardiotoxicity is manifested not only by the development of anthracycline cardiomyopathy with a high risk of convention into heart failure. It also can cause various cardiovascular pathologies, in particular cardiac syndrome X. This study described chemotherapy-induced microvascular angina in 23-year-old otherwise heathy woman. The diagnosis is challenging for doctors, since microvascular flow may be only detected by using functional test. © 2021 Elsevier Inc.