Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Surface Modification of Additive Manufactured Ti6al4v Scaffolds With Gelatin/Alginate- Igf-1 Carrier: An Effective Approach for Healing Bone Defects Publisher Pubmed

Summary: Coated titanium scaffolds boost bone healing, study shows, enhancing implant success for bone defects. #BoneRegeneration #Orthopedics

Mofazali P1 ; Atapour M1 ; Nakamura M2 ; Sheikholeslam M3 ; Galati M4 ; Saboori A4
Authors

Source: International Journal of Biological Macromolecules Published:2024


Abstract

The study investigates the potential of porous scaffolds with Gel/Alg-IGF-1 coatings as a viable candidate for orthopaedic implants. The scaffolds are composed of additively manufactured Ti6Al4V lattices, which were treated in an alkali solution to obtain the anatase and rutile phases. The treated surface exhibited hydrophilicity of <11.5°. A biopolymer carrier containing Insulin-like growth factor 1 was coated on the samples using immersion treatment. This study showed that the surface-modified porous Ti6Al4V scaffolds increased cell viability and proliferation, indicating potential for bone regeneration. The results demonstrate that surface modifications can enhance the osteoconduction and osteoinduction of Ti6Al4V implants, leading to improved bone regeneration and faster recovery. The porous Ti6Al4V scaffolds modified with surface coating of Gel/Alg-IGF-1 exhibited a noteworthy increase in cell viability (from 80.7 to 104.1%viability) and proliferation. These results suggest that the surface modified scaffolds have potential for use in treating bone defects. © 2024 Elsevier B.V.
Related Docs
View other Related Docs
1. Fabrication and Characterization of Two-Layered Nanofibrous Membrane for Guided Bone and Tissue Regeneration Application, Materials Science and Engineering C (2017)
2. Synthesis and Characterization of Bioactive Glass Coated Forsterite Scaffold for Tissue Engineering Applications, Journal of Alloys and Compounds (2017)
3. Modified Mechanical Coating Technique for the Preparation of Nanohydroxyapatite Coated Ti–6Al–4V Dental Implants, Protection of Metals and Physical Chemistry of Surfaces (2020)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (7)
Mohammad Rafienia (4)
Surface Modification of Additive Manufactured Ti6al4v Scaffolds With Gelatin/Alginate- Igf-1 Carrier: An Effective Approach for Healing Bone Defects
Other Related Docs
4. Review of Recent Advances in Bone Scaffold Fabrication Methods for Tissue Engineering for Treating Bone Diseases and Sport Injuries, Tissue and Cell (2024)
5. Fabrication and Characterization of Novel Polyhydroxybutyrate-Keratin/Nanohydroxyapatite Electrospun Fibers for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2022)
6. Development of Porous Photopolymer Resin-Swcnt Produced by Digital Light Processing Technology Using for Bone Femur Application, Archives of Bone and Joint Surgery (2021)
7. Fabrication of 3D Porous Polyurethane-Graphene Oxide Scaffolds by a Sequential Two-Step Processing for Non-Load Bearing Bone Defects, Physica Scripta (2024)
8. Evaluation of Physical, Mechanical and Biological Properties of Bioglass/Titania Scaffold Coated With Poly (3-Hydroxybutyrate)-Chitosan for Bone Tissue Engineering Applications, Materials Technology (2020)
9. Evaluation of Physical, Mechanical and Biological Properties of Β-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nano Composite Scaffold for Bone Tissue Engineering Application, Materials Technology (2021)
10. Evaluation of the Effects of Nano-Tio2 on Bioactivity and Mechanical Properties of Nano Bioglass-P3hb Composite Scaffold for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2016)
11. Evaluation of Mg63 Cells Behavior With Electrospun Nanocomposite Scaffolds of Polycaprolactone and Carbon Quantum Dot Containing Captopril for Bone Tissue Engineering, Journal of Knowledge and Health in Basic Medical Sciences (2020)
12. 3D-Printed Polycaprolactone/Mesoporous Bioactive Glass Composite Scaffolds With Mg and Zr Ions for Bone Tissue Engineering, Heliyon (2025)
13. Zein/Zno-Modified 3D-Printed Pcl/Sphene Scaffolds With Improved Bacterial Inhibition and Osteoblast Activity for Bone Regeneration Applications, ACS Biomaterials Science and Engineering (2025)
14. The Effect of Porosity on the Mechanical Properties of Porous Titanium Scaffolds: Comparative Study on Experimental and Analytical Values, Materials Research Express (2018)
15. The Influence of Bioglass Nanoparticles on the Biodegradation and Biocompatibility of Poly (3-Hydroxybutyrate) Scaffolds, International Journal of Artificial Organs (2012)
16. Mechanical Evaluation of Nhap Scaffold Coated With Poly-3-Hydroxybutyrate for Bone Tissue Engineering, Journal of Nanoscience and Nanotechnology (2013)
17. A Novel Three-Dimensional-Printed Polycaprolactone/Nanohydroxyapatite-Nanoclay Scaffold for Bone Tissue Engineering Applications, Journal of Bionic Engineering (2025)
18. The Journey of Multifunctional Bone Scaffolds Fabricated From Traditional Toward Modern Techniques, Bio-Design and Manufacturing (2020)
19. An Overview of Biodegradable Polymers: Revolutionizing Biomedical Applications by Increasing Stability and Biocompatibility for Biomaterial Applications From Lumen-Apposing Metal Stents to Dental Implants, Nanochemistry Research (2025)
20. Evaluation of the Effects of Starch on Polyhydroxybutyrate Electrospun Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2021)