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Covid-19 and the Potential of Janus Family Kinase (Jak) Pathway Inhibition: A Novel Treatment Strategy Publisher



Khaledi M1 ; Sameni F1 ; Yahyazade S2 ; Radandish M2 ; Owlia P3 ; Bagheri N4 ; Afkhami H5 ; Mahjoor M6 ; Esmaelpour Z7 ; Kohansal M8 ; Aghaei F4
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Molecular Microbiology Research Center, Faculty of Medicine, Shahed University, Tehran, Iran
  4. 4. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. Shahed University, Tehran, Iran
  6. 6. Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Reference Laboratory for Bovine Tuberculosis, Razi Vaccine and Serum Research Institute, Karaj, Iran
  8. 8. Department of Medical Biotechnology, Fasa University of Medical Sciences, Fasa, Iran

Source: Frontiers in Medicine Published:2022


Abstract

Recent evidence proposed that the severity of the coronavirus disease 2019 (COVID-19) in patients is a consequence of cytokine storm, characterized by increased IL-1β, IL-6, IL-18, TNF-α, and IFN-γ. Hence, managing the cytokine storm by drugs has been suggested for the treatment of patients with severe COVID-19. Several of the proinflammatory cytokines involved in the pathogenesis of COVID-19 infection recruit a distinct intracellular signaling pathway mediated by JAKs. Consequently, JAK inhibitors, including baricitinib, pacritinib, ruxolitinib, and tofacitinib, may represent an effective therapeutic strategy for controlling the JAK to treat COVID-19. This study indicates the mechanism of cytokine storm and JAK/STAT pathway in COVID-19 as well as the medications used for JAK/STAT inhibitors. Copyright © 2022 Khaledi, Sameni, Yahyazade, Radandish, Owlia, Bagheri, Afkhami, Mahjoor, Esmaelpour, Kohansal and Aghaei.
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