Thalidomide Reduces the Level of Nitric Oxide in Bleomycin Induced Pulmonary Fibrosis Model

Thalidomide Reduces the Level of Nitric Oxide in Bleomycin Induced Pulmonary Fibrosis Model

Nematbakhsh M¹ ; Rafieyan S¹ ; Mirkheshti N¹ ; Alavi A¹ ; Rajabi P¹ ; Khazaei M¹

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1. Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Clinical and Experimental Medical Letters Published:2009

Abstract

Introduction: Idiopathic pulmonary fibrosis is a disease with unfavorable prognosis with no effective treatment. Nitric Oxide (NO) may play an important function in the pathophysiology of the disease. In this project, the effect of thalidomide on serum NO level in a model of lung fibrosis was studied. Material and Methods: Sixteen male wistar rats in three groups were introduced in this experimental study. The first group had intra-trachea injection of bleomycin to obtain a fibrosis model, and thalidomide was given for 30 days as treatment. The other two groups received bleomycin and normal saline respectively. The level of Nitrite (NI, stable metabolite of NO) was measured. Results: The serum level of NI was reduced in the first group, and it was significantly different from other groups; group 11.79±0.58 ,group 2: 7.79±2.22 and group 3: 6.99±1.32 μmole/l, p<0.05. Discussion: Thalidomide may have an inhibitory effect on NO production which is helpful for the pulmonary fibrosis treatment. © Akademia Medycyny 2009.

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Style	Citing Format
MLA	Nematbakhsh M, et al.. "Thalidomide Reduces the Level of Nitric Oxide in Bleomycin Induced Pulmonary Fibrosis Model." Clinical and Experimental Medical Letters, vol. 50, no. 2, 2009, pp. 75-76.
APA	Nematbakhsh M, Rafieyan S, Mirkheshti N, Alavi A, Rajabi P, Khazaei M (2009). Thalidomide Reduces the Level of Nitric Oxide in Bleomycin Induced Pulmonary Fibrosis Model. Clinical and Experimental Medical Letters, 50(2), 75-76.
Chicago	Nematbakhsh M, Rafieyan S, Mirkheshti N, Alavi A, Rajabi P, Khazaei M. "Thalidomide Reduces the Level of Nitric Oxide in Bleomycin Induced Pulmonary Fibrosis Model." Clinical and Experimental Medical Letters 50, no. 2 (2009): 75-76.
Harvard	Nematbakhsh M et al. (2009) 'Thalidomide Reduces the Level of Nitric Oxide in Bleomycin Induced Pulmonary Fibrosis Model', Clinical and Experimental Medical Letters, 50(2), pp. 75-76.
Vancouver	Nematbakhsh M, Rafieyan S, Mirkheshti N, Alavi A, Rajabi P, Khazaei M. Thalidomide Reduces the Level of Nitric Oxide in Bleomycin Induced Pulmonary Fibrosis Model. Clinical and Experimental Medical Letters. 2009;50(2):75-76.
BibTex	@article{ author = {Nematbakhsh M and Rafieyan S and Mirkheshti N and Alavi A and Rajabi P and Khazaei M}, title = {Thalidomide Reduces the Level of Nitric Oxide in Bleomycin Induced Pulmonary Fibrosis Model}, journal = {Clinical and Experimental Medical Letters}, volume = {50}, number = {2}, pages = {75-76}, year = {2009} }
RIS	TY - JOUR AU - Nematbakhsh M AU - Rafieyan S AU - Mirkheshti N AU - Alavi A AU - Rajabi P AU - Khazaei M TI - Thalidomide Reduces the Level of Nitric Oxide in Bleomycin Induced Pulmonary Fibrosis Model JO - Clinical and Experimental Medical Letters VL - 50 IS - 2 SP - 75 EP - 76 PY - 2009 ER -

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