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Exosomes and Micrornas: New Potential Therapeutic Candidates in Alzheimer Disease Therapy Publisher Pubmed



Iranifar E1 ; Seresht BM2 ; Momeni F3 ; Fadaei E4 ; Mehr MH5 ; Ebrahimi Z6 ; Rahmati M7 ; Kharazinejad E8 ; Mirzaei H9
Authors
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Authors Affiliations
  1. 1. Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
  2. 2. Department of Genetics, Faculty of Biological Science, Shahid Beheshti University (GC), Tehran, Iran
  3. 3. General Practitioner, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Faculty of Medicine, Islamic Azad University of Najafabad, Najafabad, Iran
  5. 5. Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Biotechnology and Molecular Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  7. 7. Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  8. 8. Abadan School of Medical Sciences, Abadan, Iran
  9. 9. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Cellular Physiology Published:2019


Abstract

Exosomes are biological nanocarriers which could be involved in a variety of basic physiological events. They exert their effects via targeting their cargos (i.e., DNAs, messenger RNAs, microRNAs [miRNAs], and proteins) to host cells, which led to change behaviors of recipient cells. One of the important aspects of exosomes is the roles of them in disease conditions. Increasing evidence indicated that exosomes are one of the main players in Alzheimer’s disease (AD) pathogenesis. Hence, it seems that these nanocarriers could be used as diagnostic and therapeutic biomarkers in AD treatment. Another important player in AD pathogenesis is miRNA. MiRNAs are short noncoding RNAs which exert their effects as epigenetic regulators. These molecules involved in different stages of AD. Therefore, miRNAs could be used as prognostic, diagnostic, and therapeutic biomarkers in AD. Here, we summarized various roles of exosomes and application of them in AD pathogenesis. Moreover, we highlighted the utilization of miRNAs as a therapeutic option in AD therapy. © 2018 Wiley Periodicals, Inc.
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