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Chemopreventive and Therapeutic Potential of Curcumin in Esophageal Cancer: Current and Future Status Publisher Pubmed



Hesari A1 ; Azizian M2 ; Sheikhi A3 ; Nesaei A4 ; Sanaei S5 ; Mahinparvar N5 ; Derakhshani M6 ; Hedayt P6 ; Ghasemi F7 ; Mirzaei H8
Authors
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Authors Affiliations
  1. 1. Molecular and Medicine Research Center, Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
  2. 2. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
  3. 3. Department of Medical Biochemistry, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran
  4. 4. Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
  5. 5. General Practitioner, Medical Researcher, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Pathology, Medical University of Isfahan, Isfahan, Iran
  7. 7. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  8. 8. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

Source: International Journal of Cancer Published:2019


Abstract

Esophageal cancer is a common malignant tumor with an increasing trend during the past three decades. Currently, esophagectomy, often in combination with neoadjuvant chemo- and radiotherapy, is the cornerstone of curative treatment for esophageal cancer. However, esophagostomy is related to significant risks of perioperative mortality and morbidity, as well as lengthy recovery. Moreover, the adjuvant therapies including chemotherapy and radiotherapy are associated with numerous side effects, limiting compliance and outcome. The dietary agent curcumin has been extensively studied over the past few decades and is known to have many biological activities especially in regard to the prevention and potential treatment of cancer. This review summarizes the chemo-preventive and chemotherapeutic potential of curcumin in esophageal cancer in both preclinical and clinical settings. © 2018 UICC
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