Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Involvement of Aberrant Regulation of Epigenetic Mechanisms in the Pathogenesis of Parkinson's Disease and Epigenetic-Based Therapies Publisher Pubmed



Renani PG1 ; Taheri F1 ; Rostami D2 ; Farahani N3 ; Abdolkarimi H4 ; Abdollahi E5 ; Taghizadeh E6, 7 ; Gheibi Hayat SM8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Genetic Department, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
  2. 2. Department of School Allied, Zabol University of Medical Sciences, Zabol, Iran
  3. 3. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
  5. 5. Department of Medical Genetics, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran
  6. 6. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  7. 7. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Journal of Cellular Physiology Published:2019


Abstract

Parkinson's disease (PD) is known as a progressive neurodegenerative disorder associated with the reduction of dopamine-secreting neurons and the formation of Lewy bodies in the substantia nigra and basal ganglia routes. Aging, as well as environmental and genetic factors, are considered as disease risk factors that can make PD as a complex one. Epigenetics means studying heritable changes in gene expression or function, without altering the underlying DNA sequence. Multiple studies have shown the association of epigenetic variations with onset or progression of various types of diseases. DNA methylation, posttranslational modifications of histones and presence of microRNA (miRNA) are among epigenetic processes involved in regulating pathways related to the development of PD. Unlike genetic mutations, most epigenetic variations may be reversible or preventable. Therefore, the return of aberrant epigenetic events in different cells is a growing therapeutic approach to treatment or prevention. Currently, there are several methods for treating PD patients, the most important of which are drug therapies. However, detection of genes and epigenetic mechanisms involved in the disease can develop appropriate diagnosis and treatment of the disease before the onset of disabilities and resulting complications. The main purpose of this study was to review the most important epigenetic molecular mechanisms, epigenetic variations in PD, and epigenetic-based therapies. © 2019 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. Novel Insights Into the Role of Circular Rnas in Parkinson Disease: An Emerging Renaissance in the Management of Neurodegenerative Diseases, Journal of Neuroscience Research (2022)
2. Elucidating the Role of a Shared Lncrna-Mirna-Mrna Network in Exacerbating Parkinson's Disease Symptoms in the Context of Covid-19 Infection, Gene Expression The Journal of Liver Research (2024)
3. Mevalonate Cascade and Neurodevelopmental and Neurodegenerative Diseases: Future Targets for Therapeutic Application, Current Molecular Pharmacology (2016)
4. Epi-Drugs and Epi-Mirs: Moving Beyond Current Cancer Therapies, Current Cancer Drug Targets (2016)
5. Coordinated Modification in Expression Levels of Hspa1a/B, Dgkh, and Notch2 in Parkinson’S Patients’ Blood and Substantia Nigra As a Diagnostic Sign: The Transcriptomes’ Relationship, Neurological Sciences (2023)
6. Discovery of Novel Hit Compounds As Potential Hdac1 Inhibitors: The Case of Ligand- and Structure-Based Virtual Screening, Computers in Biology and Medicine (2021)
7. Significant Modulations of Linc001128 and Linc0938 With Mir-24-3P and Mir-30C-5P in Parkinson Disease, Scientific Reports (2022)
8. Lncrnas As Putative Biomarkers and Therapeutic Targets for Parkinson’S Disease, Neurological Sciences (2021)
Experts (# of related papers)
View all Related Experts
Masoud Etemadifar (4)
Rasoul Salehi (3)
Other Related Docs
9. Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors, Molecules (2020)
10. Sirna and Epigenetic Aberrations in Ovarian Cancer, Journal of Cancer Research and Therapeutics (2016)
11. Effects of Caloric Restriction on Delaying the Aging Process, Journal of Isfahan Medical School (2013)
12. Noggin Along With a Self-Assembling Peptide Nanofiber Containing Long Motif of Laminin Induces Tyrosine Hydroxylase Gene Expression, Molecular Neurobiology (2017)
13. Using Whole Exome Sequencing in Determining the Genetic Cause of Parkinson Disease in an Iranian Family, Neurology Asia (2021)
14. The Role of Micrornas in the Pathophysiology of Human Central Nervous System: A Focus on Neurodegenerative Diseases, Ageing Research Reviews (2023)
15. A Compound Downregulation of Srrm2 and Mir-27A-3P With Upregulation of Mir-27B-3P in Pbmcs of Parkinson’S Patients Is Associated With the Early Stage Onset of Disease, PLoS ONE (2020)
16. Pretreatment With Crocin Along With Treadmill Exercise Ameliorates Motor and Memory Deficits in Hemiparkinsonian Rats by Anti-Inflammatory and Antioxidant Mechanisms, Metabolic Brain Disease (2019)
17. Nlrp3 Inflammasome: Its Regulation and Involvement in Atherosclerosis, Journal of Cellular Physiology (2018)
18. Non-Coding Rnas and Neurodegenerative Diseases: Information of Their Roles in Apoptosis, Molecular Neurobiology (2024)
19. The Potential of Targeting Autophagy-Related Non-Coding Rnas in the Treatment of Alzheimer’S and Parkinson’S Diseases, Cellular and Molecular Neurobiology (2024)
20. Molecular Mechanisms of Drug Resistance in Ovarian Cancer, Journal of Cellular Physiology (2018)
21. Cutting Edge: Metabolic Immune Reprogramming, Reactive Oxygen Species, and Cancer, Journal of Cellular Physiology (2021)
22. Regulation of Dna Methylation Machinery by Epi-Mirnas in Human Cancer: Emerging New Targets in Cancer Therapy, Cancer Gene Therapy (2021)
23. A Clinical and Molecular Genetic Study of 50 Families With Autosomal Recessive Parkinsonism Revealed Known and Novel Gene Mutations, Molecular Neurobiology (2018)
24. Epigenetics and Common Non Communicable Disease, Advances in Experimental Medicine and Biology (2019)
25. Micrornas and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy, Molecular Neurobiology (2022)