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Triglyceride-Glucose Index (Tyg) As a Novel Biomarker in the Era of Cardiometabolic Medicine Publisher Pubmed



Avagimyan A1 ; Pogosova N2, 3 ; Fogacci F4 ; Aghajanova E5 ; Djndoyan Z6 ; Patoulias D7 ; Sasso LL8 ; Bernardi M9 ; Faggiano A10, 11 ; Mohammadifard N12 ; Neglia D13 ; Carugo S10, 11 ; Cicero A14, 15 ; Rizzo M16, 17 Show All Authors
Authors
  1. Avagimyan A1
  2. Pogosova N2, 3
  3. Fogacci F4
  4. Aghajanova E5
  5. Djndoyan Z6
  6. Patoulias D7
  7. Sasso LL8
  8. Bernardi M9
  9. Faggiano A10, 11
  10. Mohammadifard N12
  11. Neglia D13
  12. Carugo S10, 11
  13. Cicero A14, 15
  14. Rizzo M16, 17
  15. Biondizoccai G9, 18
  16. De Caterina R19
  17. Sarrafzadegan N20, 21
Show Affiliations
Authors Affiliations
  1. 1. Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Deputy Director of Research and Preventive Cardiology, National Medical Research Centre of Cardiology named after E. Chazov, Moscow, Russian Federation
  3. 3. Head of Evidence-Based Medicine Department, Institute of Medicine, Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation
  4. 4. Atherosclerosis and Metabolic Disorders Research Unit, University of Bologna, Bologna, Italy
  5. 5. Head of Endocrinology Department, Head of Endocrinology Unit of Muratsan University Clinic, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  6. 6. Head of Internal Diseases Propaedeutics Department, Head of Internal Diseases Unit, Mikaelyan University Clinic, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  7. 7. Outpatient Department of Cardiometabolic Medicine, Second Department of Cardiology, General Hospital “Hippokration”, Aristotle University of Thessaloniki, Thessaloniki, Greece
  8. 8. Catholic University of the Sacred Heart, Rome, Italy
  9. 9. Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
  10. 10. Department of Cardio-Thoracic-Vascular Area, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
  11. 11. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
  12. 12. Head of Nutrition Department, Cardiovascular Research Institute the WHO Collaborative Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  13. 13. Cardiovascular Department, CNR Research Area, Fondazione CNR/Regione Toscana Gabriele Monasterio, Pisa, Italy
  14. 14. Hypertension and Cardiovascular Risk Research Unit, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy
  15. 15. Cardiovascular Medicine Unit, IRCCS Policlinico S. Orsola-Malpighi di Bologna, Bologna, Italy
  16. 16. Head of Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, School of Medicine, University of Palermo, Italy
  17. 17. Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai, United Arab Emirates
  18. 18. Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
  19. 19. Head of Cardiology Department, University of Pisa, Pisa, Italy
  20. 20. Director of Cardiovascular Research Institute WHO Collaboration Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  21. 21. School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada

Source: International Journal of Cardiology Published:2025


Abstract

In the period of increasing prevalence of metabolic disorders such as obesity and diabetes, healthcare professionals are facing significant challenges. Therefore, an accurate global assessment of insulin resistance is of utmost importance. Current medical research is focused on identifying an easily accessible and reproducible gold-standard surrogate marker for insulin resistance. Ideally, such a marker would enable healthcare providers to predict the risk of type 2 diabetes and cardiovascular diseases. The triglyceride-glucose index (TyG) is a promising marker for preventive cardiology and cardiometabolic medicine. This narrative review article aims to provide a comprehensive evaluation of the credibility of TyG as a surrogate marker of insulin resistance among patients at different stages across the cardiometabolic continuum. This assessment fully complies with evidence-based medicine and offers valuable insight into the clinical utility of TyG. © 2024
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