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Relationship Between Serum Resistin Concentrations With Metabolic Syndrome and Its Components in an Iranian Population Publisher Pubmed



Asgary S1 ; Samsamshariat SZ2 ; Ghorbani A2 ; Keshvari M1 ; Sahebkar A3 ; Sarrafzadegan N1
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Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2015


Abstract

Background The aim of the study is to determine the association of resistin with each MetS component. Methods This study had a case-control design, and its data was retrieved from the Isfahan Healthy Heart Program (IHHP), Serum samples from 44 subjects with MetS (diagnosed according to the NCEP-ATPIII criteria) and 46 healthy controls were analyzed for resistin using enzyme-linked immunosorbent assay. Association between serum resistin and levels of total (TC), low- (LDL-C) and high-density (HDL-C) lipoprotein cholesterol, triglycerides (TG), fasting blood sugar (FBS), waist circumference, body mass index, and systolic and diastolic blood pressures was determined. Results Serum resistin levels were significantly higher in the MetS compared with control group (3.64 ± 1.63, P = 0.040). Serum levels of resistin were found to be significantly correlated with levels of TC (r = -0.347; P = 0.027) and LDL-C (r = -0.311; P = 0.050), but not other components of MetS including systolic and diastolic blood pressure, TG, HDL-C and FBS (P > 0.05) in the MetS group, after adjustment for age, gender and BMI. No significant correlation between resistin and MetS components was observed in the control group (P > 0.05). Conclusion Serum resistin levels are elevated in subjects with MetS and may be associated with the severity of this syndrome. © 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved.
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