The First Rare and Fatal Case of Invasive Aspergillosis of Spinal Cord Due to Aspergillus Nidulansin an Iranian Child With Chronic Granulomatosis Disease: Review of Literature

The First Rare and Fatal Case of Invasive Aspergillosis of Spinal Cord Due to Aspergillus Nidulansin an Iranian Child With Chronic Granulomatosis Disease: Review of Literature Publisher

Tavakoli M¹ ; Hedayati MT² ; Mirhendi H³ ; Nouripoursisakht S⁴ ; Hedayati N⁵ ; Saghafi F⁶ ; Mamishi S⁷

Show Affiliations

1. Student Research Committee, Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3. Department of Medical Mycology and Parasitology, Isfahan University of Medical Sciences, Isfahan, Iran
4. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
5. Student Research Committee, Invasive Fungi Research Center, Sari, Iran
6. Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
7. Department of Infectious Diseases, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Medical Mycology Published:2020

Abstract

Background and Purpose: Invasive aspergillosis (IA) of the central nervous system (CNS) is a devastating complication which is rarely reported in immunocompromised children. In this case presentation, we reported a rare and fatal IA with spinal cord involvement in a 10-year-old child with X-linked chronic granulomatosis disease (CGD). Case report: The child had a previous history of pulmonary tuberculosis. A cervical spine X-ray revealed the involvement of cervical vertebrae (T4/T5) and ribs causing spinal cord compression and epidural abscess. The patient underwent a decompressive laminectomy and mass removal. The histopathology and culture results suggested IA. Despite the aggressive and prolonged therapy, he died within one year. Aspergillus nidulans was identified as the causative agent based on morphological and molecular studies. Conclusion: This synopsis represents the aggressive behavior of infection caused by A. nidulans in the CGD patient. © 2020 Mazandaran University of Medical Sciences. All rights reserved.

2. Central Nervous System Aspergillosis in an Immunocompetent Patient, Neurosciences (2010)

3. Cerebral Phaeohyphomycosis Due to Rhinocladiella Mackenziei in Persian Gulf Region: A Case and Review, Mycoses (2018)

4. Pregnancy, Child Bearing and Prevention of Giving Birth to the Affected Children in Patients With Primary Immunodeficiency Disease; a Case-Series, BMC Pregnancy and Childbirth (2018)

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Style	Citing Format
MLA	Tavakoli M, et al.. "The First Rare and Fatal Case of Invasive Aspergillosis of Spinal Cord Due to Aspergillus Nidulansin an Iranian Child With Chronic Granulomatosis Disease: Review of Literature." Current Medical Mycology, vol. 6, no. 1, 2020, pp. 55-60.
APA	Tavakoli M, Hedayati MT, Mirhendi H, Nouripoursisakht S, Hedayati N, Saghafi F, Mamishi S (2020). The First Rare and Fatal Case of Invasive Aspergillosis of Spinal Cord Due to Aspergillus Nidulansin an Iranian Child With Chronic Granulomatosis Disease: Review of Literature. Current Medical Mycology, 6(1), 55-60.
Chicago	Tavakoli M, Hedayati MT, Mirhendi H, Nouripoursisakht S, Hedayati N, Saghafi F, Mamishi S. "The First Rare and Fatal Case of Invasive Aspergillosis of Spinal Cord Due to Aspergillus Nidulansin an Iranian Child With Chronic Granulomatosis Disease: Review of Literature." Current Medical Mycology 6, no. 1 (2020): 55-60.
Harvard	Tavakoli M et al. (2020) 'The First Rare and Fatal Case of Invasive Aspergillosis of Spinal Cord Due to Aspergillus Nidulansin an Iranian Child With Chronic Granulomatosis Disease: Review of Literature', Current Medical Mycology, 6(1), pp. 55-60.
Vancouver	Tavakoli M, Hedayati MT, Mirhendi H, Nouripoursisakht S, Hedayati N, Saghafi F, et al.. The First Rare and Fatal Case of Invasive Aspergillosis of Spinal Cord Due to Aspergillus Nidulansin an Iranian Child With Chronic Granulomatosis Disease: Review of Literature. Current Medical Mycology. 2020;6(1):55-60.
BibTex	@article{ author = {Tavakoli M and Hedayati MT and Mirhendi H and Nouripoursisakht S and Hedayati N and Saghafi F and Mamishi S}, title = {The First Rare and Fatal Case of Invasive Aspergillosis of Spinal Cord Due to Aspergillus Nidulansin an Iranian Child With Chronic Granulomatosis Disease: Review of Literature}, journal = {Current Medical Mycology}, volume = {6}, number = {1}, pages = {55-60}, year = {2020} }
RIS	TY - JOUR AU - Tavakoli M AU - Hedayati MT AU - Mirhendi H AU - Nouripoursisakht S AU - Hedayati N AU - Saghafi F AU - Mamishi S TI - The First Rare and Fatal Case of Invasive Aspergillosis of Spinal Cord Due to Aspergillus Nidulansin an Iranian Child With Chronic Granulomatosis Disease: Review of Literature JO - Current Medical Mycology VL - 6 IS - 1 SP - 55 EP - 60 PY - 2020 ER -

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