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Evaluation of Leishmanicidal Activity of Oxypeucedanin and Isoimperatorin on Leishmania Major Promastigotes



Sajjadi SE1 ; Eskandarian AA2 ; Yousefi HA2 ; Mansourian M3 ; Taheri M4
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan Pharmaceutical Sciences Research Center and Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2013

Abstract

Background: Leishmaniasis has a wide range of clinical symptoms including cutaneous, mucocutaneous, and visceral leishmaniasis. Recently, advances have been observed in the field of using herbal medicines for the treatment of leishmaniasis. The study aimed to determine the in-vitro effect of two prenylated coumarins (oxypeucedanin and isoimperatorin) of Prangos ferulaceae (L.) Lindl with positive and negative controls on Leishmania major. Methods: To have stationary phase of the growth curve, the parasites were cultured in NNN (Novy-MacNeal-Nicolle) and RPMI-1640 (Roswell Park Memorial Institute 1640) medias in the incubator. Then a certain amount of culture, containing approximately one million parasites, were exposed to oxypeucedanin and isoimperatorin and their effects were investigated after 3, 6, 24, 48, and 72 hours. Findings: Non of the concentrations of oxypeucedanin and isoimperatorin had leishmanicidal effect compared to the positive control (P < 0.05). Conclusion: Oxypeucedanin and isoimperatorin do not have leishmanicidal effect on Leishmania major promastigotes.
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