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Diagnostic Value of Prostate-Specific Antigen in Women With Polycystic Ovary Syndrome



Mardanian F1 ; Heidari N1
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Authors Affiliations
  1. 1. Department of Obstetric and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2011

Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. Its presentationis that of irregular menstruation associated with ovulation defects. Because of adverse outcomes such as metabolic andcardiovascular disorders, its diagnosis and treatment is very important. Therefore, the diagnostic value of prostatespecificantigen (PSA) in women with polycystic ovary syndrome was evaluated.METHODS: A total of 32 women with PCOS and 32 aged matched healthy females were recruited in this case-controlstudy. The subjects were compared by means of metabolic measures and serum PSA level. The correlations betweenthese markers were evaluated. Sensitivity and specificity values and cut off levels of PSA were established for diagnosisof PCOS.RESULTS: Mean PSA, Ferriman Gallwey score (FGS), luteinizing hormone/follicle stimulating hormone ratio(LH/FSH), testosterone, dehydroepiandrosterone sulfate (DHEAS), 17α hydroxyprogesterone (17α HP) levels weresignificantly higher in PCOS (P<0.001, respectively). PSA levels greater than 0.07 ng/ml yielded a sensitivity of 91%and specificity of 82%, and was helpful as a diagnostic tool for women with PCOS. Circulating androgens and hirsutismwere associated with higher levels of PSA in PCOS women.CONCLUSIONS: Our results showed direct correlation between PSA, hirsutism and hyperandrogenism state. Therefore, itseems logical to use PSA level for detection of hyperandrogenism state in women.
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