A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos)

A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos) Publisher

Summary: Novel androgens 11-KT and DHT show potential for PCOS diagnosis, correlating well with standard markers. Could they change evaluation? #PCOS #Androgens

Kumar N ; Sharma N ; Roy S ; Chawla I ; Sharma LK

Source: Advanced Biomedical Research Published:2025

Abstract

Background: The measurement of androgens (testosterone and dehydroepiandrosterone sulfate (DHEAS)) remains standard for the evaluation of polycystic ovarian syndrome (PCOS) women. However, other early novel androgen markers, 5 alpha-dihydrotestosterone (DHT) and 11-ketotestosterone (11-KT), may open a separate path of measurement, which may be more potent. The study was conducted with the objectives to analyze the association of 11-KT and DHT with established markers and with the clinical profile of PCOS patients. Materials and Methods: A case-control study was conducted on 30 newly diagnosed cases of PCOS as per the Rotterdam criteria and 30 age-matched controls. The estimation of testosterone, DHEAS, 11-KT, and DHT was performed by the enzyme-linked immunoassay (ELISA) method. The assessment of biochemical and hormonal parameters was compared and correlated with 11-KT and DHT. Results: Compared to the controls, cases had significantly higher 11-KT (20.81 ± 3.53 vs. 15.83 ± 2.67 nmol/L, P < 0.0001) and DHT (154.39 vs. 71.02 pg/mL, P < 0.0001). 11-KT showed a significant positive correlation with total testosterone (TT) (r = 0.555) and DHEAS (r = 0.501). DHT also showed a significant positive correlation with TT (r = 0.487) and DHEAS (r = 0.52). Conclusion: In conclusion, novel androgen derivatives (11-KT and DHT) hold equivalent evidence for the evaluation of women with PCOS as they are raised in women with PCOS as compared to controls. Moreover, they show a good correlation with the standard markers currently used for PCOS. © 2025 Elsevier B.V., All rights reserved.

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A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos)

Style	Citing Format
MLA	Kumar N, et al.. "A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos)." Advanced Biomedical Research, vol. 14, no. 1, 2025, pp. -.
APA	Kumar N, Sharma N, Roy S, Chawla I, Sharma LK (2025). A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos). Advanced Biomedical Research, 14(1), -.
Chicago	Kumar N, Sharma N, Roy S, Chawla I, Sharma LK. "A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos)." Advanced Biomedical Research 14, no. 1 (2025): -.
Harvard	Kumar N et al. (2025) 'A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos)', Advanced Biomedical Research, 14(1), pp. -.
Vancouver	Kumar N, Sharma N, Roy S, Chawla I, Sharma LK. A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos). Advanced Biomedical Research. 2025;14(1):-.
BibTex	@article{ author = {Kumar N and Sharma N and Roy S and Chawla I and Sharma LK}, title = {A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos)}, journal = {Advanced Biomedical Research}, volume = {14}, number = {1}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Kumar N AU - Sharma N AU - Roy S AU - Chawla I AU - Sharma LK TI - A Case-Control Study of the Association of Novel Androgens (11-Kt and Dht), Classical Androgens (Testosterone and Dheas), Hormones (Lh, Fsh, 17-Ohp, Insulin, and Shbg), Insulin Resistance (Homa-Ir), and Dyslipidemia in Polycystic Ovarian Syndrome (Pcos) JO - Advanced Biomedical Research VL - 14 IS - 1 SP - EP - PY - 2025 ER -

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