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3-Keto Umbilicagenin a and B, New Sapogenins From Allium Umbilicatum Boiss Publisher Pubmed



Sadeghi M1 ; Zolfaghari B1 ; Troiano R2 ; Lanzotti V2
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Isfahan University of Medical Sciences, Hezar Jerib Avenue, Isfahan, 73461, Iran
  2. 2. Dipartimento di Agraria, Universita di Napoli Federico II, Via Universita 100, Portici, Naples, 80055, Italy

Source: Fitoterapia Published:2015


Abstract

Two sapogenins, named 3-keto umbilicagenin A and B (1 and 2), possessing a novel chemical structure with a 3-keto group on the spirostane skeleton, have been isolated from Allium umbilicatum Boiss. Their chemical structure has been established through a combination of extensive spectroscopic analysis, mainly nuclear magnetic resonance and mass spectrometry, and chemical methods as (25R)-3-keto-spirostan-2α,5α,6β-triol (1) and (25R)-3-keto-spirostan-2α,5α-diol (2). The isolated compounds were tested for cytotoxic activity on J-774, murine monocyte/macrophage, and WEHI-164, murine fibrosarcoma cell lines. © 2015 Elsevier B.V. All rights reserved.
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