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Immunohistochemical Distinction of Metastases of Renal Cell Carcinoma With Molecular Analysis of Overexpression of the Chemokines Cxcr2 and Cxcr3 As Independent Positive Prognostic Factors for the Tumorigenesis Publisher Pubmed



Rezakhaniha B1 ; Dormanesh B2 ; Pirasteh H3 ; Yahaghi E4 ; Masoumi B5 ; Ziari K6 ; Rahmani O6
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Authors Affiliations
  1. 1. Department of Urology, AJA University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatric Nephrology, AJA University of Medical Sciences, Tehran, Iran
  3. 3. Department of Nephrology, AJA University of Medical Sciences, Tehran, Iran
  4. 4. Department of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Department of Emergency Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Pathology, Be'sat Hospital, AJA University of Medical Sciences, Tehran, Iran

Source: IUBMB Life Published:2016


Abstract

Renal cell carcinoma (RCC) represents, on average, over 90% of all malignancies of the kidney that occur in adults in both sexes. Chemokine receptors expression has been found in many kinds of cancer and at tumor metastasis site. We determined CXCR2 and CXCR3 expression in RCC by immunohistochemistry method and analyzed the prognostic value of these markers. Our finding demonstrated that CXCR3 were highly overexpressed in renal cancer tissues compared with those adjacent normal kidney tissues (P < 0.001). The results showed that high expression of CXCR3 was markedly correlated with metastasis (P = 0.021) and tumor stage (P = 0.031). CXCR2 were overexpressed in renal cancer tissues compared with those adjacent normal kidney tissues (P < 0.001). Our result showed that CXCR2 expression was correlated with high grade (P = 0.024), advanced stage (P = 0.029) and metastasis (P = 0.018). The log-rank test revealed that high CXCR2 and CXCR3 expressions are related to poorer overall survival (P < 0.001; P < 0.001). In conclusion, this study indicates the correlation of CXCR3 and CXCR3 with progression of RCC. In addition, high CXCR3 andCXCR2 expressions were correlated with shorter overall survival. © 2016 IUBMB Life, 68(8):629–633, 2016. © 2016 International Union of Biochemistry and Molecular Biology
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