Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id

Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study Publisher Pubmed

Erdem H^{1, 2} ; Kocoglu E³ ; Ankarali H⁴ ; Elsokkary R⁵ ; Hakamifard A^{6, 7} ; Karaali R⁸ ; Kulzhanova S⁹ ; Elkholy A¹⁰ ; Tehrani HA¹¹ ; Khedr R¹² ; Kayakalem A¹³ ; Pandak N¹⁴ ; Caglasonmezer M¹⁵ ; Nizamuddin S¹⁶ Show All Authors

Erdem H^{1, 2}
Kocoglu E³
Ankarali H⁴
Elsokkary R⁵
Hakamifard A^{6, 7}
Karaali R⁸
Kulzhanova S⁹
Elkholy A¹⁰
Tehrani HA¹¹
Khedr R¹²
Kayakalem A¹³
Pandak N¹⁴
Caglasonmezer M¹⁵
Nizamuddin S¹⁶
Berkcam H¹⁷
Guner R¹³
Elkholy JA¹⁸
Llopis F¹⁹
Marino A²⁰
Stebel R²¹
Szabo BG²²
Belitova M²³
Fadel E²⁴
Yetisyigit T²⁴
Cag Y²⁵
Alkan S²⁶
Kayaaslan B¹³
Oncu S²⁷
Ozdemir M²⁸
Yilmaz M²⁹
Isik AC³⁰
Baskol D³¹
Sincan G³²
Cascio A³³
Ozerbalin S³⁴
Korkmaz N³⁵
Ripon RK³⁶
Abbas S³⁷
Dumitru IM³⁸
Eserkarlidag G³⁹
Lanzafame M⁴⁰
Rafey A³⁷
Raza A³⁷
Sipahi OR³¹
Darazam IA⁴¹
Elbahr U¹
Erdem I⁴²
Ergen P²⁵
Bilir C^{43, 44}
Caskurlu H²⁵
Erdem A⁴⁵
Makek MJ⁴⁶
Altindis M⁴⁷
Lakatos B²²
Luca CM⁴⁸
Yilmaz EM⁴⁹
Nsutebu E⁵⁰
Cakmak R²⁹
Sirmatel F⁵¹

Source: International Journal of Antimicrobial Agents Published:2023

Abstract

Objectives: Bacteraemia during the course of neutropenia is often fatal. We aimed to identify factors predicting mortality to have an insight into better clinical management. Methods: The study has a prospective, observational design using pooled data from febrile neutropenia patients with bacteraemia in 41 centres in 16 countries. Polymicrobial bacteraemias were excluded. It was performed through the Infectious Diseases–International Research Initiative platform between 17 March 2021 and June 2021. Univariate analysis followed by a multivariate binary logistic regression model was used to determine independent predictors of 30-d in-hospital mortality (sensitivity, 81.2%; specificity, 65%). Results: A total of 431 patients were enrolled, and 85 (19.7%) died. Haematological malignancies were detected in 361 (83.7%) patients. Escherichia coli (n = 117, 27.1%), Klebsiellae (n = 95, 22% %), Pseudomonadaceae (n = 63, 14.6%), Coagulase-negative Staphylococci (n = 57, 13.2%), Staphylococcus aureus (n = 30, 7%), and Enterococci (n = 21, 4.9%) were the common pathogens. Meropenem and piperacillin-tazobactam susceptibility, among the isolated pathogens, were only 66.1% and 53.6%, respectively. Pulse rate (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002–1.034), quick SOFA score (OR, 2.857; 95% CI, 2.120–3.851), inappropriate antimicrobial treatment (OR, 1.774; 95% CI, 1.011–3.851), Gram-negative bacteraemia (OR, 2.894; 95% CI, 1.437–5.825), bacteraemia of non-urinary origin (OR, 11.262; 95% CI, 1.368–92.720), and advancing age (OR, 1.017; 95% CI, 1.001–1.034) were independent predictors of mortality. Bacteraemia in our neutropenic patient population had distinctive characteristics. The severity of infection and the way to control it with appropriate antimicrobials, and local epidemiological data, came forward. Conclusions: Local antibiotic susceptibility profiles should be integrated into therapeutic recommendations, and infection control and prevention measures should be prioritised in this era of rapidly increasing antibiotic resistance. © 2023 Elsevier Ltd and International Society of Antimicrobial Chemotherapy

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Style	Citing Format
MLA	Erdem H, et al.. "Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study." International Journal of Antimicrobial Agents, vol. 62, no. 3, 2023, pp. -.
APA	Erdem H, Kocoglu E, Ankarali H, Elsokkary R, Hakamifard A, Karaali R, Kulzhanova S, Elkholy A, Tehrani HA, Khedr R, Kayakalem A, Pandak N, Caglasonmezer M, Nizamuddin S, Berkcam H, Guner R, Elkholy JA, Llopis F, Marino A, ... Sirmatel F (2023). Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study. International Journal of Antimicrobial Agents, 62(3), -.
Chicago	Erdem H, Kocoglu E, Ankarali H, Elsokkary R, Hakamifard A, Karaali R, Kulzhanova S, et al.. "Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study." International Journal of Antimicrobial Agents 62, no. 3 (2023): -.
Harvard	Erdem H et al. (2023) 'Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study', International Journal of Antimicrobial Agents, 62(3), pp. -.
Vancouver	Erdem H, Kocoglu E, Ankarali H, Elsokkary R, Hakamifard A, Karaali R, et al.. Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study. International Journal of Antimicrobial Agents. 2023;62(3):-.
BibTex	@article{ author = {Erdem H and Kocoglu E and Ankarali H and Elsokkary R and Hakamifard A and Karaali R and Kulzhanova S and Elkholy A and Tehrani HA and Khedr R and Kayakalem A and Pandak N and Caglasonmezer M and Nizamuddin S and Berkcam H and Guner R and Elkholy JA and Llopis F and Marino A and Stebel R and Szabo BG and Belitova M and Fadel E and Yetisyigit T and Cag Y and Alkan S and Kayaaslan B and Oncu S and Ozdemir M and Yilmaz M and Isik AC and Baskol D and Sincan G and Cascio A and Ozerbalin S and Korkmaz N and Ripon RK and Abbas S and Dumitru IM and Eserkarlidag G and Lanzafame M and Rafey A and Raza A and Sipahi OR and Darazam IA and Elbahr U and Erdem I and Ergen P and Bilir C and Caskurlu H and Erdem A and Makek MJ and Altindis M and Lakatos B and Luca CM and Yilmaz EM and Nsutebu E and Cakmak R and Sirmatel F}, title = {Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study}, journal = {International Journal of Antimicrobial Agents}, volume = {62}, number = {3}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Erdem H AU - Kocoglu E AU - Ankarali H AU - Elsokkary R AU - Hakamifard A AU - Karaali R AU - Kulzhanova S AU - Elkholy A AU - Tehrani HA AU - Khedr R AU - Kayakalem A AU - Pandak N AU - Caglasonmezer M AU - Nizamuddin S AU - Berkcam H AU - Guner R AU - Elkholy JA AU - Llopis F AU - Marino A AU - Stebel R AU - Szabo BG AU - Belitova M AU - Fadel E AU - Yetisyigit T AU - Cag Y AU - Alkan S AU - Kayaaslan B AU - Oncu S AU - Ozdemir M AU - Yilmaz M AU - Isik AC AU - Baskol D AU - Sincan G AU - Cascio A AU - Ozerbalin S AU - Korkmaz N AU - Ripon RK AU - Abbas S AU - Dumitru IM AU - Eserkarlidag G AU - Lanzafame M AU - Rafey A AU - Raza A AU - Sipahi OR AU - Darazam IA AU - Elbahr U AU - Erdem I AU - Ergen P AU - Bilir C AU - Caskurlu H AU - Erdem A AU - Makek MJ AU - Altindis M AU - Lakatos B AU - Luca CM AU - Yilmaz EM AU - Nsutebu E AU - Cakmak R AU - Sirmatel F TI - Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study JO - International Journal of Antimicrobial Agents VL - 62 IS - 3 SP - EP - PY - 2023 ER -

Style

Citing Format

MLA

Erdem H, et al.. "Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study." International Journal of Antimicrobial Agents, vol. 62, no. 3, 2023, pp. -.

APA

Erdem H, Kocoglu E, Ankarali H, Elsokkary R, Hakamifard A, Karaali R, Kulzhanova S, Elkholy A, Tehrani HA, Khedr R, Kayakalem A, Pandak N, Caglasonmezer M, Nizamuddin S, Berkcam H, Guner R, Elkholy JA, Llopis F, Marino A, ... Sirmatel F (2023). Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study. International Journal of Antimicrobial Agents, 62(3), -.

Chicago

Erdem H, Kocoglu E, Ankarali H, Elsokkary R, Hakamifard A, Karaali R, Kulzhanova S, et al.. "Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study." International Journal of Antimicrobial Agents 62, no. 3 (2023): -.

Harvard

Erdem H et al. (2023) 'Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study', International Journal of Antimicrobial Agents, 62(3), pp. -.

Vancouver

Erdem H, Kocoglu E, Ankarali H, Elsokkary R, Hakamifard A, Karaali R, et al.. Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study. International Journal of Antimicrobial Agents. 2023;62(3):-.

BibTex

@article{ author = {Erdem H and Kocoglu E and Ankarali H and Elsokkary R and Hakamifard A and Karaali R and Kulzhanova S and Elkholy A and Tehrani HA and Khedr R and Kayakalem A and Pandak N and Caglasonmezer M and Nizamuddin S and Berkcam H and Guner R and Elkholy JA and Llopis F and Marino A and Stebel R and Szabo BG and Belitova M and Fadel E and Yetisyigit T and Cag Y and Alkan S and Kayaaslan B and Oncu S and Ozdemir M and Yilmaz M and Isik AC and Baskol D and Sincan G and Cascio A and Ozerbalin S and Korkmaz N and Ripon RK and Abbas S and Dumitru IM and Eserkarlidag G and Lanzafame M and Rafey A and Raza A and Sipahi OR and Darazam IA and Elbahr U and Erdem I and Ergen P and Bilir C and Caskurlu H and Erdem A and Makek MJ and Altindis M and Lakatos B and Luca CM and Yilmaz EM and Nsutebu E and Cakmak R and Sirmatel F}, title = {Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study}, journal = {International Journal of Antimicrobial Agents}, volume = {62}, number = {3}, pages = {-}, year = {2023} }

RIS

TY - JOUR
AU - Erdem H
AU - Kocoglu E
AU - Ankarali H
AU - Elsokkary R
AU - Hakamifard A
AU - Karaali R
AU - Kulzhanova S
AU - Elkholy A
AU - Tehrani HA
AU - Khedr R
AU - Kayakalem A
AU - Pandak N
AU - Caglasonmezer M
AU - Nizamuddin S
AU - Berkcam H
AU - Guner R
AU - Elkholy JA
AU - Llopis F
AU - Marino A
AU - Stebel R
AU - Szabo BG
AU - Belitova M
AU - Fadel E
AU - Yetisyigit T
AU - Cag Y
AU - Alkan S
AU - Kayaaslan B
AU - Oncu S
AU - Ozdemir M
AU - Yilmaz M
AU - Isik AC
AU - Baskol D
AU - Sincan G
AU - Cascio A
AU - Ozerbalin S
AU - Korkmaz N
AU - Ripon RK
AU - Abbas S
AU - Dumitru IM
AU - Eserkarlidag G
AU - Lanzafame M
AU - Rafey A
AU - Raza A
AU - Sipahi OR
AU - Darazam IA
AU - Elbahr U
AU - Erdem I
AU - Ergen P
AU - Bilir C
AU - Caskurlu H
AU - Erdem A
AU - Makek MJ
AU - Altindis M
AU - Lakatos B
AU - Luca CM
AU - Yilmaz EM
AU - Nsutebu E
AU - Cakmak R
AU - Sirmatel F
TI - Prospective Analysis of Febrile Neutropenia Patients With Bacteraemia: The Results of an International Id–Iri Study
JO - International Journal of Antimicrobial Agents
VL - 62
IS - 3
SP -
EP -
PY - 2023
ER -

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