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Assessment of Cytological Changes of Oral Mucosa in the Patients With Gastroesophageal Reflux Disease: An Analytical Cross-Sectional Study Publisher



Torabinia N1 ; Samim F2 ; Khatoonabadi S3 ; Badri P4 ; Keshani F5
Authors
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Authors Affiliations
  1. 1. Department of Oral and Maxillofacial Pathology, Dental Materials Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. McGill faculty of dental medicine and oral health, Montreal, QC, Canada
  3. 3. Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Faculty of Medicine and Dentistry, School of Dentistry, University of Alberta, Edmonton, AB, Canada
  5. 5. Dental Research Center, Department of Oral and Maxillofacial Pathology, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Dental Hypotheses Published:2024


Abstract

Introduction: This study aims to investigate cytological changes of oral mucosa in patients with gastroesophageal reflux disease (GERD). Methods: In this cross-sectional study, 25 patients with GERD and 25 healthy persons underwent buccal mucosa brush biopsy for cytological assessment. The observed cellular changes were categorized(14) as Class I: normal; Class II: atypical; Class III: intermediate; Class IV: suggestive of cancer; Class V: positive for cancer. Results: All 50 participants (mean age 39.9± 11.8, 24 male) completed the study and were included in statistical analysis. Ordinal logistic regression (overall model test p<0.001) showed GERD was a significant predicator for cytological changes of the oral mucosa (p<0.001). Age and gender were not significant predicators (p>0.05). Conclusion: GERD is associated with cellular alterations in the buccal mucosa, which can be detected by cytology. The most common outcomes were nuclear hyperchromatism and grade II cellular changes. © 2024 Dental Hypotheses | Published by Wolters Kluwer - Medknow
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