Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Interaction Between Cetp Taq1b Polymorphism and Hei, Dqi and Dpi on Metabolic Biomarkers in Patients With Type 2 Diabetes Publisher Pubmed



Kalantar Z1 ; Sotoudeh G2 ; Esmaeily Z2 ; Rafiee M3 ; Koohdani F1, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Nutrition, School of Nutrition & Food sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Diabetic Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Human Nutrition and Dietetics Published:2022


Abstract

Background: Type 2 diabetes mellitus (T2DM) is a multidimensional consequence of environmental and genetic factors. Cholesteryl ester transfer protein (CETP) Taq1B polymorphism has been reported as a main predictor of dyslipidaemia, comprising an important complication in persons with T2DM. However, diet could affect T2DM patients metabolic health. Methods: We investigated the combination of gene–diet effects on some metabolic biomarkers. In our cross-sectional study, blood samples of 220 patients were collected. Dietary indices (healthy eating index, dietary quality index and dietary phytochemical index) were obtained from a validated semi-quantitative food frequency questionnaire. CETP Taq1B polymorphism was genotyped by a polymerase chain reaction-restriction fragment polymorphism method. Data were analysed by analysis of covariance. Results: The interaction between the CETP Taq1B polymorphism and dietary indices on low density lipoprotein/high density lipoprotein was significant (p < 0.001 both crude and adjusted models). In addition, the interaction between polymorphism and dietary quality index on total antioxidant capacity (p = 0.004 crude model, p = 0.005 after adjusting) and pentraxin 3 (p = 0.01 both crude and adjusted models) was significant. Also, the interaction between polymorphism and healthy eating index on waist circumference (p = 0.005 both crude and adjusted models) and dietary phytochemical index on interleukin-18 (p = 0.03 crude model) was significant. Conclusions: Our results indicated the effect of CETP Taq1B polymorphism on some inflammatory and anthropometrics markers (total antioxidant capacity, pentraxin 3, interleukin-18, low density lipoprotein/high density lipoprotein and waist circumference) with high and low adherence to dietary incides. © 2021 The British Dietetic Association Ltd.
Related Docs
View other Related Docs
1. Dietary Acid Load and Its Interaction With Cetp Taqb1 Polymorphisms on Lipid Profile Among Patients With Type 2 Diabetes Mellitus, BMC Endocrine Disorders (2023)
2. Dietary Quality Indices Modify the Effects of Apolipoprotein B Polymorphisms on Biochemical and Anthropometric Factors in Type 2 Diabetes Mellitus, Scientific Reports (2021)
3. Interaction Between Cetp Polymorphism and Dietary Insulin Index and Load in Relation to Cardiovascular Risk Factors in Diabetic Adults, Scientific Reports (2021)
4. Interaction Between the Dietary Indices and Ppar-Γ Pro12ala Gene Variants on Cardiovascular Risk Factors in Patients With Type 2 Diabetes Mellitus, International Journal of Clinical Practice (2021)
5. Interactions of Bdnf Val66met and Dietary Indices in Relation to Metabolic Markers Among Patient With Type 2 Diabetes Mellitus: A Cross-Sectional Study, Journal of Health, Population and Nutrition (2023)
6. Interaction of Cholesterol Ester Transfer Protein Polymorphisms, Body Mass Index, and Birth Weight With the Risk of Dyslipidemia in Children and Adolescents: The Caspian‐Iii Study, Iranian Journal of Basic Medical Sciences (2015)
7. Apoa2-256T > C Polymorphism Interacts With Healthy Eating Index, Dietary Quality Index-International and Dietary Phytochemical Index to Affect Biochemical Markers Among Type 2 Diabetic Patients, British Journal of Nutrition (2022)
8. A Personalised Diet Study: The Interaction Between Apoa2 −265T > C Polymorphism and Dietary Inflammatory Index on Oxidative and Inflammatory Markers and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study, International Journal of Clinical Practice (2021)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (47)
Roya Kelishadi (40)
Other Related Docs
9. Healthy Eating Index and Cardiovascular Risk Factors Among Iranian Elderly Individuals, ARYA Atherosclerosis (2017)
10. A Nutrigenetic Approach to Investigate Apob Ecor1 Polymorphism-Dietary Acid Load Interactions on Lipid and Anthropometric-Related Outcomes in Adults With Dyslipidemic Type 2 Diabetes, Lifestyle Genomics (2023)
11. Adherence to Lifelines Diet Score and Risk Factors of Metabolic Syndrome Among Overweight and Obese Adults: A Cross-Sectional Study, Frontiers in Nutrition (2022)
12. The Relationship Between Healthy Eating Index and Lipid Profile in Healthy Individuals: A Systematic Review, International Journal of Preventive Medicine (2024)
13. The Relationship Between Dietary Phytochemical Index and Novel Anthropometric Indices and the Severity of Diabetic Foot Ulcers in Adults With Type 2 Diabetes: A Cross-Sectional Study, BMC Endocrine Disorders (2024)
14. Dietary Glycemic Index and Glycemic Load Mediate the Effect of Cartpt Rs2239670 Gene Polymorphism on Metabolic Syndrome and Metabolic Risk Factors Among Adults With Obesity, BMC Endocrine Disorders (2022)
15. Dietary Phytochemical Index in Relation to Risk of Stroke: A Case-Control Study, Nutritional Neuroscience (2022)
16. The Association Between Dietary Diversity Score and Food Insecurity and Novel Cardiovascular Risk Factors in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study, Journal of Diabetes and Metabolic Disorders (2025)
17. How Is Healthy Eating Index-2015 Related to Risk Factors for Cardiovascular Disease in Patients With Type 2 Diabetes, Frontiers in Nutrition (2023)
18. Dietary Acid Load Modifies the Effects of Apoa2–265 T > C Polymorphism on Lipid Profile and Serum Leptin and Ghrelin Levels Among Type 2 Diabetic Patients, BMC Endocrine Disorders (2022)
19. The Relation Between Dietary Phytochemical Index and Metabolic Health Status in Overweight and Obese Adolescents, Scientific Reports (2023)
20. Association of Major Dietary Patterns With Advanced Glycation End Products and High-Sensitivity C-Reactive Protein in People With Type 1 Diabetes Mellitus, Nutrition Journal (2023)
21. Healthy Eating Index and Cardiovascular Risk Factors Among Iranians, Journal of the American College of Nutrition (2013)
22. Dietary Phytochemical Index and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study Among Iranian Adults, Complementary Therapies in Medicine (2022)
23. Association Between Type 2 Diabetes and Different Types of Dietary Fats: A Case-Control Study, Clinical Nutrition ESPEN (2023)
24. The Association of Dietary Phytochemical Index and Nonalcoholic Fatty Liver Disease, Food Science and Nutrition (2023)
25. The Effect of Fads2 Gene Rs174583 Polymorphism on Desaturase Activities, Fatty Acid Profile, Insulin Resistance, Biochemical Indices, and Incidence of Type 2 Diabetes, Journal of Research in Medical Sciences (2018)
26. Adherence to Alternative Healthy Eating Index (Ahei-2010) Is Not Associated With Risk of Stroke in Iranian Adults: A Case-Control Study, International Journal for Vitamin and Nutrition Research (2021)
27. A Personalised Diet Approach Study: Interaction Between Ppar-Γ Pro12ala and Dietary Insulin Indices on Metabolic Markers in Diabetic Patients, Journal of Human Nutrition and Dietetics (2022)
28. Dietary Phytochemical Index and Its Relationship With Diabetic Sensorimotor Polyneuropathy: A Case-Control Study, Scientific Reports (2024)
29. Dietary Phytochemical Index in Relation to Metabolic Health Status, Serum Adropin, and Brain-Derived Neurotrophic Factor Levels in Adults, Current Developments in Nutrition (2024)
30. How Dietary Patterns Could Have a Role in Prevention, Progression, or Management of Diabetes Mellitus? Review on the Current Evidence, Journal of Research in Medical Sciences (2012)
31. The Association of the Paraoxonase 1 Q192r Polymorphism With Coronary Artery Disease (Cad) and Cardiometabolic Risk Factors in Iranian Patients Suspected of Cad, Frontiers in Cardiovascular Medicine (2023)
32. Dietary Energy Density Is Inversely Associated With the Diet Quality Indices Among Iranian Young Adults, Journal of Nutritional Science and Vitaminology (2012)
33. Longitudinal Association Between an Overall Diet Quality Index and Latent Profiles of Cardiovascular Risk Factors: Results From a Population Based 13-Year Follow up Cohort Study, Nutrition and Metabolism (2021)
34. Adherence to Healthy Eating Index-2010 Is Inversely Associated With Metabolic Syndrome and Its Features Among Iranian Adult Women, European Journal of Clinical Nutrition (2017)
35. Association of Dietary Phytochemical Index and Mental Health in Women: A Cross-Sectional Study, British Journal of Nutrition (2019)
36. Association of Dietary Total Antioxidant Capacity to Anthropometry in Healthy Women: A Cross-Sectional Study, Nutrition (2020)
37. Prediction of Dyslipidemia Using Gene Mutations, Family History of Diseases and Anthropometric Indicators in Children and Adolescents: The Caspian-Iii Study, Computational and Structural Biotechnology Journal (2018)
38. Diet Quality Among Iranian Adolescents Needs Improvement, Public Health Nutrition (2015)
39. Adherence to a Healthy Diet and Odds of Metabolic Syndrome: A Cross-Sectional Study, Clinical Nutrition ESPEN (2023)
40. Genetic Association With Low Concentrations of High Density Lipoprotein-Cholesterol in a Pediatric Population of the Middle East and North Africa: The Caspian-Iii Study, Atherosclerosis (2014)
41. The Product of Triglycerides and Glucose in Comparison With Fasting Plasma Glucose Did Not Improve Diabetes Prediction, Acta Diabetologica (2015)
42. Dietary Intake of Linoleic Acid, Its Concentrations, and the Risk of Type 2 Diabetes: A Systematireview and Dose-Response Meta-Analysis of Prospective Cohort Studies, Diabetes Care (2021)
43. Low Levels of High-Density Lipoprotein Cholesterol Do Not Predict the Incidence of Type 2 Diabetes in an Iranian High-Risk Population: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2016)
44. Dietary Calcium Intake in Relation to Type-2 Diabetes and Hyperglycemia in Adults: A Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Scientific Reports (2022)
45. Dietary Acid Load Adopts the Effect of Apob Ins/Del Genetic Variant (Rs11279109) on Obesity Trait, Cardiovascular Markers, Lipid Profile, and Serum Leptin Level Among Patients With Diabetes: A Cross-Sectional Study, Scientific Reports (2024)
46. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
47. Cholesterol Synthesis and Absorption Markers in Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2019)
48. Interaction Between Dietary Total Antioxidant Capacity and Bdnf Val66met Polymorphism on Lipid Profiles and Atherogenic Indices Among Diabetic Patients, Scientific Reports (2021)
49. Is Any Association Between Alternate Healthy Eating Index (Ahei) With Lipid Profile and Liver Enzymes? a Cross-Sectional Study, Journal of Diabetes and Metabolic Disorders (2021)
50. Association of Dietary Pattern and Metabolic Syndrome in 15- to 49-Years-Old Women, Journal of Isfahan Medical School (2015)