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A Personalised Diet Study: The Interaction Between Apoa2 −265T > C Polymorphism and Dietary Inflammatory Index on Oxidative and Inflammatory Markers and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study Publisher Pubmed



Karimi E1 ; Tondkar P2 ; Sotoudeh G3 ; Qorbani M4, 5 ; Rafiee M6 ; Koohdani F7, 8
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetic, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetic, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Clinical Practice Published:2021


Abstract

Background: This study aimed to investigate the interaction between dietary inflammatory index (DII) and apolipoproteinA2 265T > C (ApoA2 −265T > C) polymorphism on inflammatory and oxidative markers and lipid profile in type 2 diabetes mellitus (T2DM) patients. Methods: In this cross-sectional study, 157 patients with T2DM were recruited. A food-frequency questionnaire was used for DII calculation. Inflammatory, oxidative and lipid biomarkers were measured. Real-time polymerase chain reaction (PCR) method was used for ApoA2 genotyping determination. Results: In the current study, serum 8-iso-PGF2α and CRP were significantly higher, and serum SOD activity was significantly lower in subjects with CC genotype than TT homozygous in both crude and adjusted (for DII and AAs intake) models. Also, C-allele carriers compared with people with TT genotype had lower PTX3 in both models. In addition, serum TG level was significantly higher in TC genotype than TT homozygous in adjusted model. Moreover, subjects with CC homozygous and high DII level had significantly higher 8-iso-PGF2α level compared to those with TT genotype and low DII (reference group) in adjusted (for BMI, age, sexuality and AAs intake) model. Our results also showed that in TC genotypes with low DII and CC homozygous with both low and high DII, PTX3 concentrations were significantly lower than the reference group. In addition, CC carriers with low DII had significantly higher CRP level compared to the reference group. Moreover, our results reported significant higher TG in TC genotype with low DII and also higher total cholesterol level in CC genotype with low DII than the reference group. Conclusion: These findings indicate that CC genotype might predict higher inflammatory and oxidative status level compared to T allele carriers. An inflammatory diet may accelerate oxidative stress in subjects with CC genotype. However, the association between APOA2 −265T > C polymorphism and inflammation and lipid profile is presented less modifiable by DII. © 2021 John Wiley & Sons Ltd.
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